Tramadol EP Impurity D ( and Enantiomer) CAS 80456-81-1
| CAS No. | 80456-81-1 |
| Molecular Formula | C15H23NO2 |
| Molecular Weight | 249.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Tramadol EP Impurity D ( and Enantiomer) (CAS 80456-81-1) is a certified pharmaceutical impurity reference standard with the molecular formula C15H23NO2 and a molecular weight of 249.35 g/mol.
The molecular framework of Tramadol EP Impurity D ( and Enantiomer) (C15H23NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H23NO2 |
| Molecular Weight | 249.35 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 1 |
Related Tramadol Standards
- Tramadol Impurity 10 (CAS 192384-41-1)
- Tramadol Hydrochloride EP Impurity C (CAS 905592-54-3)
- Tramadol Impurity 20 (CAS CATO-C4X-149820)
- (-)-Tramadol (CAS 123134-25-8)
- Tramadol EP Impurity A (CAS 152538-36-8)
- Tramadol Impurity 4 (CAS 2914-77-4)
- Tramadol Impurity 21 (CAS CATO-C4X-149821)
- Tramadol Impurity 2 (CAS 187219-95-0)
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