Captopril EP Impurity B CAS 80629-35-2
| CAS No. | 80629-35-2 |
| Molecular Formula | C9H14BrNO3 |
| Molecular Weight | 264.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Captopril EP Impurity B (CAS 80629-35-2) is a certified pharmaceutical impurity reference standard with the molecular formula C9H14BrNO3 and a molecular weight of 264.12 g/mol.
The molecular framework of Captopril EP Impurity B (C9H14BrNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H14BrNO3 |
| Molecular Weight | 264.12 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Captopril Standards
- Captopril Impurity J Hydrate Salt (CAS 801293-45-8)
- Captopril Impurity 32 (CAS 65167-28-4)
- Captopril EP Impurity J (CAS 64838-55-7)
- Captopril Impurity 40 (CAS 122130-63-6)
- Captopril EP Impurity N (CAS 65134-74-9)
- Captopril Methyl Ester (CAS 176036-41-2)
- Captopril-d3 (CAS 1356383-38-4)
- Captopril Impurity N1 (CAS 80141-53-3)
Recommended Standards
- 40775-71-1 Pyridine, 2-[(4-bromophenyl)methoxy]- (CAS 40775-71-1)
- Pirfenidone Impurity 20 (CAS 377756-15-5)
- SMER 28 (CAS 307538-42-7)
- Pirfenidone Impurity 24 (CAS 912570-13-9)
- Metformin Impurity 538 (CAS CATO-C4X-1220538)
- Bortezomib Impurity N46 (CAS 85167-14-2)
- Carglumic Acid impurity 02 (CAS 196394-49-7)
- 9-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)nonanoic acid (CAS 212688-52-3)
- (3-Bromophenyl)(1,5-dioxa-9-azaspiro[5.5]undecan-9-yl)methanone (CAS 1328339-47-4)
- Omeprazole impurity 32 (CAS CATO-C4X-125532)
- (2S,3S)-Methyl 2-(benzylamino)-3-methylpentanoate hydrochloride (CAS 402929-56-0)
- Ethyl (E)-3-(2-aminopyridin-3-yl)acrylate (CAS 104830-07-1)
- Relebactam Impurity 81 (CAS CATO-C4X-214481)
- Semaglutide impurity 80 (CAS CATO-C4X-222680)
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