Fenticonazole EP Impurity B Nitrate CAS 80639-95-8
| CAS No. | 80639-95-8 |
| Molecular Formula | C24H20Cl2N2O2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Fenticonazole EP Impurity B Nitrate (CAS 80639-95-8, C24H20Cl2N2O2SHNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fenticonazole EP Impurity B Nitrate (C24H20Cl2N2O2SHNO3) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H20Cl2N2O2S HNO3 |
| Molecular Weight | 534.41 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Fenticonazole Standards
- Fenticonazole EP Impurity D Nitrate (CAS 1313397-05-5)
- Fenticonazole EP Impurity E Nitrate (CAS 1313397-06-6)
- Fenticonazole Impurity 1 (CAS 207596-23-4)
- Fenticonazole Nitrate (CAS 73151-29-8)
- Fenticonazole EP Impurity B (CAS 80639-94-7)
- Fenticonazole EP Impurity C (CAS 80676-28-4)
- Fenticonazole EP Impurity C (CAS 80676-29-5)
- Fenticonazole Impurity 6 (CAS CATO-C4X-24916)
Recommended Standards
- Dolutegravir Impurity 55 (CAS CATO-C4X-162055)
- Vigabatrin EP Impurity E (CAS 1378466-25-1)
- Clindamycin Impurity 165 (CAS CATO-C4X-1341165)
- 1,1'-(4-Oxo-1,4-dihydropyridine-3,5-diyl)bis(ethan-1-one) (CAS 200814-04-6)
- 1-(6-Methyl[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-[(4-methylphenyl)sulfonyl]carbamate (CAS 477859-66-8)
- N-Benzylethanolamine (CAS 104-63-2)
- Anhydroicaritin (CAS 38226-86-7)
- N-(2,4-Difluoro-3-formylphenyl)-propane-1-sulfonamide (CAS 1254567-71-9)
- 7-Fluorobenzo[d]thiazol-2-amine (CAS 20358-08-1)
- Prolactin-Releasing Peptide (12-31) (human) (CAS 235433-36-0)
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