4-Chloro-5-methoxy-2-(trifluoromethyl)pyrimidine CAS 808770-41-4
| CAS No. | 808770-41-4 |
| Molecular Formula | C6H4ClF3N2O |
| Molecular Weight | 212.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 212.56 g/mol gives 4-Chloro-5-methoxy-2-(trifluoromethyl)pyrimidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Chloro-5-methoxy-2-(trifluoromethyl)pyrimidine (CAS 808770-41-4) is a high-purity analytical reference standard with the molecular formula C6H4ClF3N2O and a molecular weight of 212.56 g/mol.
The molecular framework of 4-Chloro-5-methoxy-2-(trifluoromethyl)pyrimidine (C6H4ClF3N2O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4ClF3N2O |
| Molecular Weight | 212.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-6-(2,2,2-trifluoroethoxy)pyrazine (CAS 1016530-98-5)
- 2-Chloro-3-(trifluoromethoxy)pyridin-4-amine (CAS 1221171-79-4)
- 2-Chloro-6-(trifluoromethoxy)pyridin-4-amine (CAS 1221171-99-8)
- 2-Chloro-3-(2,2,2-trifluoroethoxy)pyrazine (CAS 1251156-39-4)
- 5-Chloro-4-formyl-1-methyl-3-(trifluoromethyl)-1H-pyrazole (CAS 128455-62-9)
- 2-Chloro-4-methoxy-5-(trifluoromethyl)pyrimidine (CAS 1312535-76-4)
- 3-Chloro-5-(2,2,2-trifluoroethoxy)pyridazine (CAS 1346691-33-5)
- 3-Chloro-5-(trifluoromethoxy)pyridin-2-amine (CAS 1361852-64-3)
Recommended Standards
- 4-Chloro-2-methoxy-6-(trifluoromethyl)pyrimidine (CAS 932701-90-1)
- 5-Chloro-2-methyl-6-(trifluoromethyl)pyrimidin-4-ol (CAS 425394-36-1)
- 3-Chloro-6-(2,2,2-trifluoroethoxy)pyridazine (CAS 99366-83-3)
- 6-Chloro-2-(trifluoromethyl)-4,5-pyrimidinediamine (CAS 709-57-9)
- 5-Bromo-2-((furan-2-ylmethyl)amino)pyrimidine-4-carboxylic acid (CAS 2137822-79-6)
- 2-Phenyl-3,4-dihydro-2H-pyrrol-5-amine (CAS 82256-22-2)
- 1-(Tetrahydro-2h-pyran-4-yl)-N-((tetrahydrofuran-2-yl)methyl)methanamine (CAS 1247405-05-5)
- 2-(5-Cyano-2-hydroxy-3-methoxyphenyl)acetic acid (CAS 1807052-18-1)
- 2-(4-Methylpiperazin-1-yl)-1-phenylethan-1-amine (CAS 775349-54-7)
- 8-Bromo-2-(bromomethyl)quinoline (CAS 847861-97-6)
- Ethyl 2-isothiocyanato-5-methyl-4-phenylthiophene-3-carboxylate (CAS 861239-52-3)
- (3,4-Dimethoxyphenyl)propylamine (CAS 887588-02-5)
- 6-Methyl-3-oxo-3,4-dihydropyrazine-2-carboxamide (CAS 88394-06-3)
- PACAP-Related Peptide (PRP), rat (CAS 132769-35-8)
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