Calcium Dobesilate Impurity 8 CAS 81010-88-0
| CAS No. | 81010-88-0 |
| Molecular Formula | C6H6O8S2 |
| Molecular Weight | 270.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Calcium Dobesilate Impurity 8 (CAS 81010-88-0, C6H6O8S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Calcium Dobesilate Impurity 8 (C6H6O8S2) contains a carbohydrate-derived structure, a sulfone group. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 270.24 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6O8S2 |
| Molecular Weight | 270.24 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Sulfur Atoms | 2 |
Related Calcium Standards
- Calcium Dobesilate Impurity N3 (CAS 17724-11-7)
- Calcium Dobesilate Impurity 7 (CAS 4444-23-9)
- Calcium Dobesilate Impurity 24 (CAS CATO-C4X-205124)
- Calcium Dobesilate Impurity 25 (CAS CATO-C4X-205125)
- Calcium Dobesilate Impurity 14 (CAS CATO-C4X-205114)
- Calcium Dobesilate Impurity 26 (CAS CATO-C4X-205126)
- Calcium Dobesilate Impurity 23 (CAS CATO-C4X-205123)
- Calcium Dobesilate Impurity 4 (CAS 2429952-20-3)
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