Naproxen Impurity 47 CAS 99705-42-7
| CAS No. | 99705-42-7 |
| Molecular Formula | C13H13BrO2 |
| Molecular Weight | 281.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Naproxen Impurity 47 (CAS 99705-42-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H13BrO2 and a molecular weight of 281.15 g/mol.
Naproxen Impurity 47 (C13H13BrO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Naproxen Impurity 47 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13BrO2 |
| Molecular Weight | 281.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
Related Naproxen Standards
- Naproxen Impurity 36 (CAS CATO-C4X-170836)
- Naproxen Sodium Impurity O (CAS 156967-24-7)
- rac-Naproxen 2-Propyl Ester (CAS 68641-85-0)
- Naproxen Impurity N3 (CAS 72337-73-6)
- Naproxen EP Impurity B (CAS 60424-17-1)
- Naproxen EP Impurity B (CAS 89617-86-7)
- Naproxen Impurity 16 (CAS CATO-C4X-170816)
- Naproxen Impurity 18 (CAS 2601735-81-1)
Recommended Standards
- Tert-butyl 3-(4-bromophenyl)propiolate (CAS 342043-09-8)
- 4,4,5,5-Tetramethyl-2-[3-(4-pyridyl)phenyl]-1,3,2-dioxaborolane (CAS 1009033-83-3)
- tert-Butyl (2-(2-bromoacetamido)ethyl)carbamate (CAS 99616-36-1)
- 4-(4-Pyridyl)phenylboric Acid Pinacol Ester (CAS 1009033-87-7)
- Oxytetracycline EP Impurity B Hydrate (CAS 305833-60-7)
- Erlotinib Impurity 93 (CAS 1058132-82-3)
- Terbutaline Impurity 17 (CAS CATO-C4X-118317)
- (6-chloropyridin-2-yl)methanamine (CAS 188637-75-4)
- 4-Bromo-6-(trifluoromethyl)phthalazin-1(2H)-one (CAS 2750149-32-5)
- 5-Chloro-1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridine-3-carbaldehyde (CAS 1033463-22-7)
- 5-Bromo-N-(2-ethoxyethyl)-3-nitropyridin-2-amine (CAS 1249309-23-6)
- 2-{[(4-bromophenyl)methyl]sulfanyl}-5-[(piperidin-1-yl)methyl]-1,4-dihydropyrimidin-4-one (CAS 932379-65-2)
- Methyl 2-(methoxymethyl)-7-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylate (CAS 338751-33-0)
- Brain Injury Derived Neurotrophic Peptide (H-3914.0001) (CAS 148330-12-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com