Pravastatin Impurity 59 CAS 81131-74-0
| CAS No. | 81131-74-0 |
| Molecular Formula | C23H36O7 |
| Molecular Weight | 424.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Pravastatin Impurity 59 (CAS 81131-74-0) is a certified pharmaceutical impurity reference standard with the molecular formula C23H36O7 and a molecular weight of 424.53 g/mol.
The molecular framework of Pravastatin Impurity 59 (C23H36O7) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pravastatin Impurity 59 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H36O7 |
| Molecular Weight | 424.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
Related Pravastatin Standards
- Pravastatin (CAS 81093-37-0)
- Pravastatin EP Impurity C (CAS 159345-66-1)
- Pravastatin Methyl Ester (CAS 81131-72-8)
- 6'-Epi pravastatin Lactone (CAS 85956-23-6)
- Pravastatin 3-beta-Hydroxy Lactone (CAS 87984-67-6)
- Pravastatin EP Impurity D (CAS 85956-22-5)
- Pravastatin Diol Lactone (CAS 159345-93-4)
- Pravastatin EP Impurity G (CAS 136590-28-8)
Recommended Standards
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- 3-Amino-N-(3,4-dichlorophenyl)-2-methylpropanamide hydrochloride (CAS 1828950-29-3)
- 3-(2,4-Dimethoxyphenyl)-N-(2-fluorophenyl)-2-(2H-1,2,3,4-tetrazol-5-yl)propanamide (CAS 483995-01-3)
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- 1-Ethynyl-3-(methylsulfanyl)benzene (CAS 210905-75-2)
- Semaglutide impurity 202 (CAS CATO-C4X-2226202)
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