Etoricoxib Impurity 44 CAS 855307-79-8
| CAS No. | 855307-79-8 |
| Molecular Formula | C18H13ClN2O2S |
| Molecular Weight | 356.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Etoricoxib Impurity 44 is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Etoricoxib Impurity 44 (CAS 855307-79-8, C18H13ClN2O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Etoricoxib Impurity 44 (C18H13ClN2O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 356.83 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Etoricoxib Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13ClN2O2S |
| Molecular Weight | 356.83 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Etoricoxib Standards
- Etoricoxib Impurity 45 (CAS 855307-80-1)
- Etoricoxib Impurity 86 (CAS CATO-C4X-108086)
- Etoricoxib (CAS 202409-33-4)
- Etoricoxib Impurity 47 (CAS CATO-C4X-108047)
- Etoricoxib D3 (CAS 850896-71-8)
- Etoricoxib D4 (CAS 1131345-14-6)
- Etoricoxib Impurity 7 (CAS CATO-C4X-10807)
- Etoricoxib Impurity 8 (CAS 646459-39-4)
Recommended Standards
- N-(5-Acetyl-4-phenylthiazol-2-yl)-2-chlorobenzamide (CAS 391221-29-7)
- 6-(4-Chlorophenyl)-3-(4-ethoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (CAS 211750-08-2)
- Etizolam Impurity 23 (CAS CATO-C4X-350923)
- 3-[(4-Chlorobenzenesulfonyl)methyl]-4-(1H-pyrrol-1-yl)benzonitrile (CAS 454473-77-9)
- Rizatriptan EP Impurity G (CAS 1000673-59-5)
- Trazodone Hydrochloride EP Impurity J (CAS 1263358-12-8)
- Orforglipron Impurity 95 (CAS CATO-C4X-323495)
- 3-Amino-1,3-diazaspiro[4.4]nonane-2,4-dione (CAS 16252-62-3)
- 2-Chloro-5-(trifluoromethyl)phenyl acetate (CAS 26107-79-9)
- 1,1,2,2-Tetrafluoro-6-azaspiro[2.5]Octane hydrochloride (CAS 1955547-12-2)
- 1-(3-Chloro-4-propoxyphenyl)-2,2,2-trifluoroethan-1-one (CAS 1443336-72-8)
- 3-Acetyl-7-methoxy-2H-1-benzopyran-2-one (CAS 64267-19-2)
- Ethyl 2-hydroxy-4-methoxy-6-methylbenzoate (CAS 6110-36-7)
- Semaglutide impurity 60 (CAS CATO-C4X-222660)
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