3,3,3-Trifluoro-2-hydroxy-2-(m-tolyl)propanoic acid CAS 81182-31-2
| CAS No. | 81182-31-2 |
| Molecular Formula | C10H9F3O3 |
| Molecular Weight | 234.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3,3,3-Trifluoro-2-hydroxy-2-(m-tolyl)propanoic acid (C10H9F3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 3,3,3-Trifluoro-2-hydroxy-2-(m-tolyl)propanoic acid (CAS 81182-31-2), a certified reference material (molecular formula C10H9F3O3, MW 234.17 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9F3O3 |
| Molecular Weight | 234.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F-containing |
Related Trifluoro Standards
- Methyl 4-(2,2,2-trifluoro-1-hydroxyethyl)benzoate (CAS 1086836-85-2)
- Methyl 3-(2,2,2-trifluoro-1-hydroxyethyl)benzoate (CAS 1188323-28-5)
- 4,4,4-Trifluoro-3-hydroxy-3-phenylbutanoic Acid (CAS 1716-77-4)
- (3S)-2,4,5-Trifluoro-3-hydroxybenzenebutanoic acid (CAS 868071-17-4)
- 2-(2,2,2-Trifluoro-1-phenylethoxy)acetic acid (CAS 53623-80-6)
- 3,3,3-Trifluoro-2-hydroxy-2-(p-tolyl)propanoic acid (CAS 81170-24-3)
- 3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid (CAS 81655-41-6)
- 4-(1,1,1-Trifluoro-2-hydroxypropan-2-yl)benzoic acid (CAS 917771-42-7)
Recommended Standards
- 3-(Hydroxymethyl)-4-(2,2,2-trifluoroethoxy)benzaldehyde (CAS 2830620-92-1)
- 3-(4-Nitrophenyl)isoxazole-5-carboxylic acid (CAS 899820-05-4)
- 3-(2-(Trifluoromethyl)phenoxy)propanoic acid (CAS 926219-09-2)
- 3-[(2,2,2-trifluoroethoxy)methyl]benzoic acid (CAS 438475-19-5)
- 5-((4-Fluorobenzyl)thio)-8,9-dimethoxyimidazo[1,2-c]quinazolin-2(3H)-one (CAS 439109-12-3)
- Ethyl 7-(N-acetylacetamido)-2-(4-chlorobenzamido)benzo[b]thiophene-3-carboxylate (CAS 333774-41-7)
- Lutetium(iii) carbonate hydrate 99.99% (CAS 64360-99-2)
- Sodium Nitroprusside Dihydrate (CAS 13755-38-9)
- (2R,3S,4S,5R)-5-Hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone (CAS 911439-19-5)
- 6-Formyl-4-iodopyridine-2-sulfonyl chloride (CAS 1393533-92-0)
- 7-Fluoro-4-oxo-4H-chromene-3-carbonitrile (CAS 1159978-71-8)
- (4-Isopropoxy-3-(trifluoromethyl)phenyl)methanol (CAS 1215118-92-5)
- Levonorgestrel EP Impurity N (CAS 4222-96-2)
- Ac-(5-31)Semaglutide (CAS CATO-C4X-2226279)
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