1-[4-(Trifluoromethoxy)phenyl]pyrrolidin-2-one CAS 82049-96-5
| CAS No. | 82049-96-5 |
| Molecular Formula | C11H10F3NO2 |
| Molecular Weight | 245.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-[4-(Trifluoromethoxy)phenyl]pyrrolidin-2-one (CAS 82049-96-5), molecular formula C11H10F3NO2 and molecular weight 245.20 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1-[4-(Trifluoromethoxy)phenyl]pyrrolidin-2-one (C11H10F3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 245.20 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10F3NO2 |
| Molecular Weight | 245.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethoxy Standards
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- 2-(4-(Trifluoromethoxy)phenyl)piperidine (CAS 1019345-74-4)
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Recommended Standards
- 1-(4-(Trifluoromethyl)pyrimidin-2-yl)piperidin-4-one (CAS 937604-44-9)
- 1-bromo-8-ethyl-naphthalene (CAS 2206741-04-8)
- (S)-4-Methyl-3-(4-(trifluoromethyl)phenyl)oxazolidin-2-one (CAS 572922-96-4)
- 1-Ethyl-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-ol (CAS 832727-80-7)
- (S)-3-((tert-butoxycarbonyl)amino)tetrahydrothiophene-3-carboxylic acid (CAS 2640556-27-8)
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- 8-[(6-Iodobenzo[d][1,3]dioxol-5-yl)thio]-9H-purin-6-amine (CAS 873436-89-6)
- Cilastatin Impurity 48 (CAS CATO-C4X-196048)
- 5,6-Dimethyl-2-(thiophen-3-yl)-1H-benzo[d]imidazole (CAS 1250163-65-5)
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- 2,6-Dichloro-N-methylbenzenesulfonamide (CAS 19818-11-2)
- Methyl 5-iodo-6-methoxypicolinate (CAS 1823920-09-7)
- Biotinyl-S6 Phosphate Acceptor Peptide trifluoroacetate salt (CAS 1815618-12-2)
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