methyl 4-amino-3-[3-(trifluoromethyl)phenyl]-1,2-thiazole-5-carboxylate CAS 82424-65-5
| CAS No. | 82424-65-5 |
| Molecular Formula | C12H9F3N2O2S |
| Molecular Weight | 302.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of methyl 4-amino-3-[3-(trifluoromethyl)phenyl]-1,2-thiazole-5-carboxylate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
methyl 4-amino-3-[3-(trifluoromethyl)phenyl]-1,2-thiazole-5-carboxylate (CAS 82424-65-5), molecular formula C12H9F3N2O2S and molecular weight 302.27 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C12H9F3N2O2S, methyl 4-amino-3-[3-(trifluoromethyl)phenyl]-1,2-thiazole-5-carboxylate contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 302.27 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), methyl 4-amino-3-[3-(trifluoromethyl)phenyl]-1,2-thiazole-5-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9F3N2O2S |
| Molecular Weight | 302.27 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related methyl Standards
- (R)-2-(4-Amino-2,2-dimethyl-6-nitrochroman-4-yl)-2,2-difluoroethanol (CAS 1415108-84-7)
- 2-amino-1-(2-methoxy-4-nitro-5-phenoxyphenyl)ethan-1-one (CAS CATO-C4X-1826142)
- Benzyl 4-amino-4-(trifluoromethyl)piperidine-1-carboxylate (CAS 1260804-42-9)
- [5-(2-Amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid (CAS 261365-11-1)
- 1-[2-Amino-1-(4-trifluoromethyl-phenyl)-ethyl]-pyrrolidine-3-carboxylic acid (CAS 886364-10-9)
- Ethyl 6-amino-5-cyano-4-(3-fluorophenyl)-2-methyl-4H-pyran-3-carboxylate (CAS 332177-02-3)
- 2-Amino-6-(hydroxymethyl)-8-oxo-4-(thiophen-2-yl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile (CAS 625376-15-0)
- 3-Amino-2-(4-fluorophenyl)benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile (CAS 400085-94-1)
Recommended Standards
- Methyl 3-((2-(trifluoromethyl)pyridin-4-yl)amino)thiophene-2-carboxylate (CAS 551921-61-0)
- Flurbiprofen Impurity 140 (CAS 1531637-33-8)
- Ethyl 5-(4-triflluoromethylphenyl)-1,3,4-thiadiazole-2-carboxylate (CAS 1986908-17-1)
- Entacapone Impurity 1 (CAS 100644-89-1)
- Polyvinyl Acetate (1 g) (CAS 9003-20-7)
- 4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide (CAS 2908-71-6)
- 2-(5-Bromothiazol-2-yl)propan-2-amine (CAS 1368049-77-7)
- 1-ethylcyclohexyl acrylate (CAS 251909-25-8)
- 4,5-Dichloro-6-methoxy-1-methyl-1H-indole-2-carboxylic acid (CAS 2131751-70-5)
- N-(3,5-Dichlorophenyl)-4-oxo-4H-chromene-2-carboxamide (CAS 476298-52-9)
- 1-tridecanoyl-2-hydroxy-sn-glycero-3-phosphocholine 20559-17-5 (CAS 20559-17-5)
- 5-Phenyl-5-ethyl-2-thiobarbituric Acid (CAS 2753-74-4)
- 1-Boc-2-(aminomethyl)pyrrolidine (CAS 177911-87-4)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
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