Famotidine impurity 68 CAS 83700-77-0
| CAS No. | 83700-77-0 |
| Molecular Formula | C6H8N2O2 |
| Molecular Weight | 140.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Famotidine impurity 68.
As a process- or degradation-related impurity, Famotidine impurity 68 (CAS 83700-77-0, C6H8N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Famotidine impurity 68 (C6H8N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H8N2O2 |
| Molecular Weight | 140.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Nitrogen Atoms | 2 |
Related Famotidine Standards
- Famotidine impurity 73 (CAS 899424-17-0)
- Famotidine Impurity 57 (CAS 95853-46-6)
- Famotidine impurity 70 (CAS 874285-13-9)
- Famotidine impurity 66 (CAS 7259-54-3)
- Famotidine Impurity C21 (CAS 7120-01-6)
- Famotidine Impurity 14 (CAS 2114-02-5)
- Famotidine Impurity 41 (CAS CATO-C4X-139241)
- Famotidine Impurity 81 (CAS CATO-C4X-139281)
Recommended Standards
- Temozolomide Impurity 10 (CAS 90801-87-9)
- Pantoprazole Impurity 26 (CAS 4780-14-7)
- Sunitinib Impurity 86 (CAS 90433-88-8)
- Benserazide Impurity 32 (CAS 3955-29-1)
- Telmisartan Impurity 17 (CAS 1352492-08-0)
- Nemonoxacin Impurity 90 (CAS CATO-C4X-312890)
- Urapidil Impurity 112 (CAS CATO-C4X-1924112)
- 5-Chloro-3-(((4-chlorophenyl)thio)methyl)-1-methyl-4-((phenylthio)methyl)-1H-pyrazole (CAS 318234-40-1)
- Flecainide Impurity 11 (CAS CATO-C4X-254611)
- (Acetoxymethyl)trifluoroborate (CAS 910377-68-3)
- 2-(4-Bromophenoxy)-N,N-dimethylethylamine-d6 (CAS 1794787-00-0)
- 4-((5-Bromopyrazin-2-yl)methyl)-1-isopropylazepane (CAS 1316218-51-5)
- 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-3H-1,3-benzodiazole (CAS 2284623-82-9)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
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