Famotidine impurity 66 CAS 7259-54-3
| CAS No. | 7259-54-3 |
| Molecular Formula | C7H9NO3 |
| Molecular Weight | 155.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Famotidine impurity 66 (C7H9NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 155.15 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Famotidine impurity 66 (CAS 7259-54-3, C7H9NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H9NO3 |
| Molecular Weight | 155.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 1 |
Related Famotidine Standards
- Famotidine impurity 70 (CAS 874285-13-9)
- Famotidine Impurity C21 (CAS 7120-01-6)
- Famotidine Impurity 57 (CAS 95853-46-6)
- Famotidine Impurity 41 (CAS CATO-C4X-139241)
- Famotidine Impurity 81 (CAS CATO-C4X-139281)
- Famotidine Impurity 80 (CAS CATO-C4X-139280)
- Famotidine impurity 67 (CAS 77345-71-2)
- Famotidine impurity 68 (CAS 83700-77-0)
Recommended Standards
- Vigabatrin Impurity 9 (CAS 71107-20-5)
- Allopurinol EP Impurity D (CAS 6994-25-8)
- Potassium Clavulanate Impurity 21 (CAS CATO-C4X-114621)
- Sulfadimethoxine EP Impurity A (CAS 3289-50-7)
- Budesonide Impurity 18 (CAS CATO-C4X-138918)
- Faropenem Impurity 53 (CAS CATO-C4X-128953)
- Fulvestrant impurity 37 (CAS CATO-C4X-191737)
- 8-Bromoquinoxaline-6-carboxylic acid (CAS 1378260-89-9)
- 1,3-Diethyl 5-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-hydroxybenzene-1,3-dicarboxylate (CAS 251096-62-5)
- (2R,3S)-Methyl 3-fluoro-5-oxopyrrolidine-2-carboxylate (CAS 97315-83-8)
- 5-Bromo-2,4-dimethoxy-6-methylpyrimidine (CAS 7752-70-7)
- 3-Chloro-N-[4-(isopentyloxy)benzyl]-2-methylaniline (CAS 1040688-28-5)
- (R)-2-Amino-4-oxo-4-(tritylamino)butanoic acid hydrate (CAS 1998701-21-5)
- Hexapeptide-10 (CAS 146439-94-3)
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