Pemetrexed Impurity CAS 83795-61-3
| CAS No. | 83795-61-3 |
| Molecular Formula | C19H17N5O5 |
| Molecular Weight | 395.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Pemetrexed Impurity (CAS 83795-61-3), a pharmacopoeial impurity reference standard (molecular formula C19H17N5O5, MW 395.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Pemetrexed Impurity (C19H17N5O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 395.37 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17N5O5 |
| Molecular Weight | 395.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Nitrogen Atoms | 5 |
Related Pemetrexed Standards
- Pemetrexed Impurity 69 (CAS CATO-C4X-172669)
- Pemetrexed Impurity 64 (CAS CATO-C4X-172664)
- Pemetrexed Impurity 65 (CAS CATO-C4X-172665)
- Pemetrexed Impurity 53 (CAS 1320346-37-9)
- (+/-)-Pemetrexed (CAS 756887-58-8)
- Pemetrexed Impurity 13 (CAS CATO-C4X-172613)
- Pemetrexed (CAS 137281-23-3)
- Pemetrexed EP Impurity E (CAS 182009-04-7)
Recommended Standards
- PDB-Pfp (CAS 2088570-81-2)
- Roxadustat Impurity 100 (CAS CATO-C4X-2213100)
- N'-(3-Ethoxy-4-hydroxybenzylidene)-3-(3-nitrophenyl)-1H-pyrazole-5-carbohydrazide (CAS 302918-46-3)
- Methyl 4-acetyl-1H-indole-2-carboxylate (CAS 116686-58-9)
- Leucogen Impurity 2 (CAS CATO-C4X-28892)
- Dacomitinib Impurity 34 (CAS CATO-C4X-208634)
- Pemafibrate Impurity 96 (CAS CATO-C4X-290396)
- 2-(4-Hydroxy-1H-indol-3-yl)acetonitrile (CAS 118573-52-7)
- 4-(2-Bromoethoxy)benzeneboronic acid pinacol ester, 98% (CAS 913836-27-8)
- 5-((4-(((2-Amino-9H-purin-6-yl)oxy)methyl)benzyl)amino)-5-oxopentanoic acid (CAS 881663-34-9)
- 3-((3-Chloro-4-methylphenyl)amino)-3-oxopropanoic acid (CAS 73877-03-9)
- 2-(4-(Difluoromethyl)-5-hydroxy-6-iodopyridin-3-yl)acetonitrile (CAS 1805535-09-4)
- 3-(3-Carboxy-2,2-dimethylpropyl)-7-methoxyquinoxaline 1-oxide (CAS 77147-77-4)
- Cholecystokinin Octapeptide (desulfated) (H-2070.0005) (CAS 198483-36-2)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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