Pemetrexed Impurity 53 CAS 1320346-37-9
| CAS No. | 1320346-37-9 |
| Molecular Formula | C12H12Br2O3 |
| Molecular Weight | 364.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Pemetrexed Impurity 53 (CAS 1320346-37-9, C12H12Br2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Pemetrexed Impurity 53 (C12H12Br2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H12Br2O3 |
| Molecular Weight | 364.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
Related Pemetrexed Standards
- Pemetrexed Impurity 20 (CAS CATO-C4X-172620)
- Pemetrexed Impurity 67 (CAS CATO-C4X-172667)
- Pemetrexed Impurity 64 (CAS CATO-C4X-172664)
- Pemetrexed Impurity 69 (CAS CATO-C4X-172669)
- Pemetrexed Impurity (CAS 83795-61-3)
- Pemetrexed Impurity 34 (CAS 1320346-43-7)
- Pemetrexed Impurity 24 (CAS 869791-47-9)
- Pemetrexed Impurity N24 (CAS 1797982-74-1)
Recommended Standards
- Methyl 1,3-dibromo-4-hydroxy-5,6,7,8-tetrahydronaphthalene-2-carboxylate (CAS 2055840-68-9)
- 2,2,3,3,4,4,5,6,6,6-Decafluoro-5-(Trifluoromethyl)Hexanoic Acid (CAS 15899-29-3)
- 4-(Allyloxy)-2,3-dibromo-5-ethoxybenzaldehyde (CAS 832673-80-0)
- 2-(Bromomethyl)-4-(difluoromethyl)-6-(trifluoromethoxy)pyridine-3-acetic acid (CAS 1804753-67-0)
- Bifonazole impurity 16 (CAS CATO-C4X-156016)
- Trimethoprim EP Impurity B (CAS 30806-86-1)
- Belzutifan Impurity 3 (CAS CATO-C4X-33943)
- (6-Amino-2,3-dichlorobenzyl)amine dihydrochloride (CAS 882301-56-6)
- 5-[(Z)-2-(4-Fluorophenyl)diazen-1-yl]-4-(4-methoxyphenyl)-2-(pyridin-3-yl)pyrimidine (CAS 338962-01-9)
- Leritrelvir impurity 1 (CAS CATO-C4X-34741)
- Clindamycin Impurity 99 (CAS CATO-C4X-134199)
- 4-((4-Chloro-3-(trifluoromethyl)phenyl)sulfonamido)benzoic acid (CAS 612041-77-7)
- 1-Cyclopropyl-N-(4-fluorobenzyl)methanamine (CAS 1019538-79-4)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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