1-(3-Chloro-2-fluorophenyl)piperazine CAS 846031-34-3
| CAS No. | 846031-34-3 |
| Molecular Formula | C10H12ClFN2 |
| Molecular Weight | 214.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(3-Chloro-2-fluorophenyl)piperazine (CAS 846031-34-3) is a high-purity analytical reference standard with the molecular formula C10H12ClFN2 and a molecular weight of 214.67 g/mol.
Structurally, 1-(3-Chloro-2-fluorophenyl)piperazine (C10H12ClFN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 214.67 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(3-Chloro-2-fluorophenyl)piperazine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12ClFN2 |
| Molecular Weight | 214.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 1-(2-Chloro-6-fluorophenyl)piperazine (CAS 1121610-03-4)
- 1-(3-Chloro-4-fluorophenyl)pyrrolidin-3-amine (CAS 1181309-35-2)
- 2-Chloro-6-methoxybenzo[d]thiazol-4-amine (CAS 1190321-02-8)
- (S)-3-chloro-2-fluoro-4-(pyrrolidin-2-yl)aniline (CAS 1213194-41-2)
- (S)-2-chloro-5-fluoro-4-(pyrrolidin-2-yl)aniline (CAS 1213554-83-6)
- 2-chloro-6-ethyl-1H,4H-thieno[2,3-d]pyrimidin-4-one (CAS 1215221-49-0)
- 1-(4-chloro-2-fluorophenyl)pyrrolidin-3-amine (CAS 1248961-67-2)
- 1-(4-Chloro-3-fluorophenyl)pyrrolidin-3-amine (CAS 1250074-31-7)
Recommended Standards
- 1-(2-Chloro-5-fluorophenyl)piperazine (CAS 321602-00-0)
- 1-(3-Chloro-5-fluorophenyl)piperazine (CAS 210992-23-7)
- 1-(2-Chloro-4-fluorophenyl)piperazine (CAS 736122-94-4)
- 1-(4-Chloro-2-fluorophenyl)piperazine (CAS 515160-75-5)
- 1-Hydroxy-8-isopropoxy-3-methylanthracene-9,10-dione (CAS 919114-36-6)
- 1-Phenylpiperidine (CAS 4096-20-2)
- N-Isopropyl-N-(5-methylisoxazol-4-yl)formamide (CAS 600639-55-2)
- Ethyl 5-oxo-3-(p-tolyl)-2,5-dihydro-1,2,4-triazine-6-carboxylate (CAS 36286-78-9)
- Hex-1-en-3-yl acetate (CAS 35926-04-6)
- 1-Cyclohexylpropan-1-amine (CAS 854750-32-6)
- 3-(2-Nitroethenyl)pyridine (CAS 3156-52-3)
- 7-(Butylamino)-3-chloroquinoline-8-carbonitrile (CAS 88346-99-0)
- Pemafibrate Impurity 3 (CAS CATO-C4X-29033)
- [5-31]-Semaglutide (CAS CATO-C4X-2226263)
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