Quinoline-3-carbonyl chloride CAS 84741-86-6
| CAS No. | 84741-86-6 |
| Molecular Formula | C10H6ClNO |
| Molecular Weight | 191.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Quinoline-3-carbonyl chloride (CAS 84741-86-6), molecular formula C10H6ClNO and molecular weight 191.61 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Quinoline-3-carbonyl chloride (C10H6ClNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Quinoline-3-carbonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6ClNO |
| Molecular Weight | 191.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Quinoline Standards
- Quinoline-8-carbonyl chloride (CAS 100517-41-7)
- Quinoline-4-carbonyl chloride (CAS 50821-72-2)
- Quinoline-6-carbonyl chloride (CAS 72369-87-0)
- Quinoline-7-carbonyl chloride (CAS 206257-00-3)
- Quinoline-8-sulfinic acid (CAS 41857-93-6)
- Quinoline-5,8-dithiol (CAS 39103-20-3)
- Quinoline, 1-butyl-1,2,3,4-tetrahydro- (CAS 6613-30-5)
- Methyl quinoline-1(2H)-carboxylate (CAS 17718-14-8)
Recommended Standards
- Isoquinoline-4-carbonyl chloride (CAS 370580-85-1)
- Ethyl 3-chloro-5-methyl-4,5-dihydroisoxazole-4-carboxylate (CAS 201138-38-7)
- Anagliptin Impurity 2 (CAS 23500-18-7)
- 8-Chloroquinoline-6-carbaldehyde (CAS 916812-11-8)
- 2-((Ethyl(2-hydroxyethyl)amino)methyl)benzonitrile (CAS 1176738-33-2)
- N-(4-Fluorobenzyl)-2-(5-(hydroxymethyl)-2-(phenethylthio)-1H-imidazol-1-yl)acetamide (CAS 921505-21-7)
- {[(2S,4S)-4-methoxypyrrolidin-2-yl]methyl}dimethylamine (CAS 1932138-97-0)
- 4-(Isopropylsulfonyl)-N1-methylbenzene-1,2-diamine (CAS 1392213-96-5)
- 3-(Aminomethylene)-1,3-dihydro-2H-indole-2-thione (CAS 212390-47-1)
- N-(2-(1H-Pyrazol-3-yl)-1H-indol-6-yl)acetamide (CAS 827318-22-9)
- Pomalidomide Impurity 40 (CAS 2093416-32-9)
- 7-Hydroxy-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(1H)-one (CAS 89418-26-8)
- 7-(Tert-butyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-ol (CAS 380902-66-9)
- Human glucagon CRS (CAS 9007-92-5)
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