Olaparib Impurity 16 CAS 848136-41-4
| CAS No. | 848136-41-4 |
| Molecular Formula | C22H21FN4O3 |
| Molecular Weight | 408.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Olaparib Impurity 16.
CATO supplies Olaparib Impurity 16 (CAS 848136-41-4), a pharmacopoeial impurity reference standard (molecular formula C22H21FN4O3, MW 408.43 g/mol) used for the identification and quantification of trace impurities in APIs.
Olaparib Impurity 16 (C22H21FN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21FN4O3 |
| Molecular Weight | 408.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Olaparib Standards
- Olaparib Impurity 165 (CAS CATO-C4X-1135165)
- Olaparib Impurity 34 (CAS CATO-C4X-113534)
- Olaparib Impurity 6 (CAS 763113-06-0)
- Olaparib Impurity 85 (CAS CATO-C4X-113585)
- Olaparib Impurity 64 (CAS CATO-C4X-113564)
- Olaparib Impurity 15 (CAS 2905341-99-1)
- Olaparib impurity 114 (CAS 2742659-74-9)
- Olaparib Impurity 17 (CAS CATO-C4X-113517)
Recommended Standards
- N,N-Diethyl-4-(4-formyl-2-methoxyphenoxy)-3-nitrobenzenesulfonamide (CAS 556020-33-8)
- Baricitinib Impurity 111 (CAS CATO-C4X-2260111)
- N-(4-amino-3-methoxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)benzenesulfonamide (CAS 69563-51-5)
- Droperidol Impurity 19 (CAS CATO-C4X-276919)
- Sodium Fusidate Impurity 25 (CAS CATO-C4X-119725)
- Oxymetazoline impurity 20 (CAS CATO-C4X-172320)
- Dotinurad Impurity 188 (CAS CATO-C4X-2494188)
- Hydroxy-1,4-butanedial (CAS 7724-28-9)
- N-(3-Chloro-4-methylphenyl)-2-((3-(4-chlorophenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 578751-60-7)
- 2-(tert-Butylthio)ethanol (CAS 5396-50-9)
- (3-Fluorophenyl)(1-methyl-1H-imidazol-2-yl)methanamine (CAS 874623-46-8)
- Poly(3-dodecylthiophene-2,5-diyl), regioregular (CAS 104934-53-4)
- N-(4-Bromophenyl)-4-biphenylamine (CAS 1160294-93-8)
- Stresscopin-Related Peptide (human) (CAS 348626-74-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com