4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline CAS 848942-61-0
| CAS No. | 848942-61-0 |
| Molecular Formula | C23H25ClFN5O3 |
| Molecular Weight | 473.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline (CAS 848942-61-0), a certified reference material (molecular formula C23H25ClFN5O3, MW 473.93 g/mol) for analytical method development and quality control.
Based on its molecular formula C23H25ClFN5O3, 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 473.93 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H25ClFN5O3 |
| Molecular Weight | 473.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
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Recommended Standards
- 2-(4-(Benzyloxy)-2-chlorobenzoyl)-N-tosylhydrazine-1-carboxamide (CAS 478039-98-4)
- 7-(4-Bromobenzoyl)-3,3-dibromo-1,3-dihydro-2H-indol-2-one (CAS 1797880-03-5)
- 11-((4-Chlorophenyl)sulfonyl)-2,3-dimethoxy-5,11,12,12a-tetrahydropyrazolo[3',4':4,5]pyrido[2,1-a]isoquinolin-8(6H)-one (CAS 685107-92-0)
- Prucalopride Impurity 42 (CAS CATO-C4X-103842)
- 2-Fluoro-4-(methylsulfanyl)pyridine-3-carboxylic acid (CAS 1809161-53-2)
- 6-(4-Methoxyphenyl)-5-(pyridin-3-yl)furo[2,3-d]pyrimidin-4-amine (CAS 501693-98-7)
- 1-Cyclopropyl-1h-pyrazol-4-amine (CAS 1240567-18-3)
- (5-Methyl-isothiazol-3-yl)-methanol (CAS 1803598-19-7)
- 4-Fluoro-N-((5-phenylisoxazol-3-yl)methyl)benzamide (CAS 946344-00-9)
- 1-(2-Fluoro-4-propoxyphenyl)ethan-1-one (CAS 119774-74-2)
- 5-Chloro-1-methylimidazole-13C4 (CAS 1391052-92-8)
- 2-Amino-4-phenyl-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile (CAS 77034-27-6)
- n-(1-Benzyl-1h-pyrazol-4-yl)-6-chloro-2-methylpyrimidin-4-amine (CAS 1281119-62-7)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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