Tenofovir alafenamide Impurity 13 CAS 851456-00-3(Free Base)
| CAS No. | 851456-00-3(Free Base) |
| Molecular Formula | C15H24LiN6O5P |
| Molecular Weight | 406.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Tenofovir alafenamide Impurity 13 (CAS 851456-00-3(Free Base)) is a certified pharmaceutical impurity reference standard with the molecular formula C15H24LiN6O5P and a molecular weight of 406.30 g/mol.
The molecular framework of Tenofovir alafenamide Impurity 13 (C15H24LiN6O5P) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H24LiN6O5P |
| Molecular Weight | 406.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir disoproxil Impurity 140 (CAS CATO-C4X-1076140)
- Tenofovir alafenamide Impurity 93 (CAS CATO-C4X-179793)
- Tenofovir Impurity 62 (CAS 211364-69-1)
- Tenofovir Alafenamide Impurity 30 (CAS CATO-C4X-179730)
- Tenofovir disoproxil Impurity 135 (CAS CATO-C4X-1076135)
- Tenofovir Alafenamide Impurity 22 (CAS 376633-26-0)
- Tenofovir Alafenamide 64 (CAS CATO-C4X-179764)
- Tenofovir alafenamide Impurity 96 (CAS CATO-C4X-179796)
Recommended Standards
- 900811-38-3 (R)-4-(2-(Iodomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene 4-[(2R)-2-(iodomethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene (CAS 900811-38-3)
- 4-Chloro-N-(3-chloro-4-(2-(piperidin-1-yl)acetamido)phenyl)benzamide (CAS 332376-81-5)
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- 3-(4-Methylpiperazine-1-carbonyl)-1-(4-(trifluoromethyl)benzyl)pyridin-2(1H)-one (CAS 338782-11-9)
- (2R,5R)-methyl 5-phenylpyrrolidine-2-carboxylate (CAS 434326-93-9)
- (E)-4-((4-cyanophenyl)amino)-4-oxobut-2-enoic acid (CAS 294193-58-1)
- Ethyl (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoate (CAS 19954-66-6)
- Methyl (E)-3-(2-fluoro-6-(pyrrolidin-1-yl)pyridin-4-yl)acrylate (CAS 1228670-52-7)
- N-(4-Methylbenzylidene)-4-nitroaniline (CAS 20192-50-1)
- Des-Leu14-Tirzepatide (CAS CATO-CPTD788959)
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