Ivabradine Impurity 36 CAS 85175-59-3
| CAS No. | 85175-59-3 |
| Molecular Formula | C15H18ClNO3 |
| Molecular Weight | 295.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Ivabradine Impurity 36 (CAS 85175-59-3), a pharmacopoeial impurity reference standard (molecular formula C15H18ClNO3, MW 295.76 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Ivabradine Impurity 36 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 295.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H18ClNO3 |
| Molecular Weight | 295.76 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ivabradine Standards
- Ivabradine Impurity 27 (CAS 85175-65-1)
- Ivabradine Impurity 7 (CAS 85175-77-5)
- Ivabradine Impurity 2 (CAS 73954-34-4)
- Ivabradine Impurity 21 (CAS 1235547-07-5)
- Ivabradine impurity 93 (CAS CATO-C4X-111993)
- Ivabradine Impurity 24 (CAS CATO-C4X-111924)
- Ivabradine Impurity 20 (CAS 1235547-06-4)
- Ivabradine impurity 92 (CAS CATO-C4X-111992)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com