Ivabradine Impurity 27 CAS 85175-65-1
| CAS No. | 85175-65-1 |
| Molecular Formula | C15H20ClNO3 |
| Molecular Weight | 297.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Ivabradine Impurity 27 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 297.78 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Ivabradine Impurity 27 (CAS 85175-65-1) is a certified pharmaceutical impurity reference standard with the molecular formula C15H20ClNO3 and a molecular weight of 297.78 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ivabradine Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H20ClNO3 |
| Molecular Weight | 297.78 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ivabradine Standards
- Ivabradine Impurity 36 (CAS 85175-59-3)
- Ivabradine Impurity 7 (CAS 85175-77-5)
- Ivabradine Impurity 2 (CAS 73954-34-4)
- Ivabradine Impurity 21 (CAS 1235547-07-5)
- Ivabradine impurity 93 (CAS CATO-C4X-111993)
- Ivabradine Impurity 24 (CAS CATO-C4X-111924)
- Ivabradine Impurity 20 (CAS 1235547-06-4)
- Ivabradine impurity 92 (CAS CATO-C4X-111992)
Recommended Standards
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