6-Bromo-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one CAS 851756-48-4
| CAS No. | 851756-48-4 |
| Molecular Formula | C9H8BrN3OS |
| Molecular Weight | 286.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Bromo-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one.
6-Bromo-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (CAS 851756-48-4) is a high-purity analytical reference standard with the molecular formula C9H8BrN3OS and a molecular weight of 286.15 g/mol.
The molecular framework of 6-Bromo-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (C9H8BrN3OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Bromo-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8BrN3OS |
| Molecular Weight | 286.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 5-(4-Bromobenzyl)thiazolidine-2,4-dione (CAS 291536-43-1)
- Ethyl 2-Bromobenzothiazole-6-carboxylate (CAS 99073-88-8)
- Methyl 2-(5-chloropyrimidin-4-yl)acetate (CAS 1260813-71-5)
- 2,3,3A,4-tetrahydrocycloocta[b]furan-5-carbonitrile (CAS 141946-25-0)
- 2-(6-Oxo-1,6-dihydropyridazin-3-yl)-2-phenylacetonitrile (CAS 338753-08-5)
- 4-(3,4,5-trifluorobenzoyl)isoquinoline (CAS 1187169-84-1)
- 3-(P-tolyl)isoxazole-5-carbaldehyde (CAS 251912-67-1)
- 4-Ethoxy-n-(4-hydroxyphenyl)-n-methylbenzene-1-sulfonamide (CAS 850021-35-1)
- (4-(Difluoromethoxy)phenyl)methanol (CAS 170924-50-2)
- Ethyl 4-chloropentanoate (CAS 70786-82-2)
- 3-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1H-pyrazole-4-carbaldehyde (CAS 2044773-94-4)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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