Lifitegrast Impurity 8 CAS 851784-82-2
| CAS No. | 851784-82-2 |
| Molecular Formula | C15H17Cl2NO4 |
| Molecular Weight | 346.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Lifitegrast Impurity 8 (CAS 851784-82-2, C15H17Cl2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H17Cl2NO4, Lifitegrast Impurity 8 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 346.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H17Cl2NO4 |
| Molecular Weight | 346.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 114 (CAS CATO-C4X-2409114)
- Lifitegrast Impurity 104 (CAS CATO-C4X-2409104)
- Lifitegrast Impurity 105 (CAS CATO-C4X-2409105)
- Lifitegrast Impurity 112 (CAS CATO-C4X-2409112)
- Lifitegrast Impurity 41 (CAS 851785-19-8)
- Lifitegrast Impurity 139 (CAS CATO-C4X-2409139)
- Lifitegrast Impurity 39 (CAS 1194864-16-8)
- Lifitegrast Impurity 136 (CAS 1865726-28-8)
Recommended Standards
- Benzyl (1-(4-bromophenyl)cyclopropyl)carbamate (CAS 1187386-06-6)
- Alprazolam EP Impurity F (CAS 37945-07-6)
- tert-Butyl (5-bromo-2-hydroxybenzyl)(2-hydroxyethyl)carbamate (CAS 1217862-54-8)
- N-(4-Chloro-2-methylphenyl)-5-(2-chlorophenyl)furan-2-carboxamide (CAS 853331-38-1)
- Riluzole Impurity 7 (CAS 1456696-94-8)
- Rosuvastatin Impurity 198 (CAS 5292-43-3)
- Lenalidomide Impurity 40 (CAS CATO-C4X-190340)
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