2-chloro-N-[4-(difluoromethoxy)benzyl]-N-methylacetamide CAS 851903-50-9
| CAS No. | 851903-50-9 |
| Molecular Formula | C11H12ClF2NO2 |
| Molecular Weight | 263.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-chloro-N-[4-(difluoromethoxy)benzyl]-N-methylacetamide.
2-chloro-N-[4-(difluoromethoxy)benzyl]-N-methylacetamide (CAS 851903-50-9) is a high-purity analytical reference standard with the molecular formula C11H12ClF2NO2 and a molecular weight of 263.67 g/mol.
Structurally, 2-chloro-N-[4-(difluoromethoxy)benzyl]-N-methylacetamide (C11H12ClF2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 263.67 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-chloro-N-[4-(difluoromethoxy)benzyl]-N-methylacetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12ClF2NO2 |
| Molecular Weight | 263.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related chloro Standards
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- 2-Chloro-n-{2-[2-(difluoromethoxy)phenyl]ethyl}acetamide (CAS 793727-80-7)
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Recommended Standards
- tert-Butyl (4-chloro-2,6-difluorophenyl)carbamate (CAS 196194-59-9)
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- tert-Butyl (2-chloro-4,6-difluorophenyl)carbamate (CAS 1547764-90-8)
- tert-Butyl (5-chloro-2,4-difluorophenyl)carbamate (CAS 1429421-83-9)
- 1-(4-(3-Aminopropyl)-1,4-diazepan-1-yl)ethan-1-one (CAS 928003-94-5)
- 3-(2-Chlorophenyl)-4-((3-ethoxy-4-hydroxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-28-3)
- Tert-butyl 2-(imino(phenyl)methyl)hydrazine-1-carboxylate (CAS 159016-25-8)
- Etoposide EP Impurity O (CAS 260974-95-6)
- Brexpiprazole Impurity 47 (CAS 2060029-80-1)
- 1-(3-Chlorophenyl)-3-(3-methoxyphenyl)urea (CAS 195133-51-8)
- Ethyl 4-cyclopentyl-3-oxobutanoate (CAS 68104-99-4)
- 2-Methyl-2-(1-oxoisoindolin-2-yl)propanoic acid (CAS 144630-35-3)
- 3-(4-Oxo-4H-chromen-2-yl)benzaldehyde (CAS 228088-38-8)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
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