(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluoro-3-phenylpropanoic acid CAS 852836-39-6
| CAS No. | 852836-39-6 |
| Molecular Formula | C24H19F2NO4 |
| Molecular Weight | 423.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluoro-3-phenylpropanoic acid (C24H19F2NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluoro-3-phenylpropanoic acid (CAS 852836-39-6) is a high-purity analytical reference standard with the molecular formula C24H19F2NO4 and a molecular weight of 423.41 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluoro-3-phenylpropanoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H19F2NO4 |
| Molecular Weight | 423.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,5-difluorophenyl)propanoic acid (CAS 205526-25-6)
- (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluoro-3-phenylpropanoic acid (CAS 2349919-42-0)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,5-difluorophenyl)propanoic acid (CAS 1701877-89-5)
- 1-(4-Methylbenzenesulfonyl)-3-[2-(1H-pyrrol-1-yl)-5-(trifluoromethyl)phenyl]urea (CAS 866010-59-5)
- 2-((2,4-Dichlorobenzyl)thio)-3-(4-methoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 477330-87-3)
- (4-Fluorophenylmethyl)triphenylphosphonium chloride (CAS 3462-95-1)
- 3-(3-Chlorophenyl)-2-fluoropropiophenone (CAS 898787-24-1)
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- U66858 (CAS 99107-52-5)
- Tolvaptan Impurity 89 (CAS 137977-65-2)
- 2-(tert-Butoxy)-5-cyclopropoxy-4-methylpyridine (CAS 1243466-73-0)
- 3-amino-4-methoxy-1,8-naphthyridine-2-carboxylic acid (CAS 1346528-32-2)
- (3aS,3′aS,8aR,8′aR)-2,2′-[2-(4-Tricyclo[3.3.1.13,7]dec-1-ylphenyl)-1-[(4-tricyclo[3.3.1.13,7]dec-1-ylphenyl)methyl]ethylidene]bis[3a,8a-dihydro-8H-indeno[1,2-d]oxazole] (CAS 2757085-47-3)
- [y-Glu3]-Semaglutide Impurity 135 (CAS CATO-C4X-2226135)
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