Tolvaptan Impurity 89 CAS 137977-65-2
| CAS No. | 137977-65-2 |
| Molecular Formula | C26H24N2O3 |
| Molecular Weight | 412.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tolvaptan Impurity 89 (CAS 137977-65-2), a pharmacopoeial impurity reference standard (molecular formula C26H24N2O3, MW 412.48 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tolvaptan Impurity 89 (C26H24N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tolvaptan Impurity 89 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H24N2O3 |
| Molecular Weight | 412.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 2 |
Related Tolvaptan Standards
- Tolvaptan Impurity 124 (CAS CATO-C4X-1955124)
- Tolvaptan Impurity 118 (CAS CATO-C4X-1955118)
- Tolvaptan Impurity 9 (CAS 1432725-23-9)
- Tolvaptan Impurity 80 (CAS CATO-C4X-195580)
- Tolvaptan Impurity 129 (CAS 1448365-49-8)
- Tolvaptan Impurity 64 (CAS CATO-C4X-195564)
- Tolvaptan Impurity 4 (CAS 1133419-00-7)
- Tolvaptan Impurity 76 (CAS 2458812-63-8)
Recommended Standards
- Samidorphan impurity 1 (CAS 361525-83-9)
- Estriol Impurity 26 (CAS CATO-C4X-163726)
- Z-Leu-Phe-OH (CAS 6401-63-4)
- Naphazoline impurity 12 (CAS CATO-C4X-144012)
- Dinoprostone EP Impurity B (CAS 27415-25-4)
- Eltrombopag Impurity 66 (CAS CATO-C4X-119866)
- Maxacalcitol Impurity 18 (CAS 147725-63-1)
- 6-(2H-1,2,3-Triazol-2-yl)benzo[d]thiazole (CAS 170862-73-4)
- Ethyl 2-acetamido-3-4-6-tri-O-acetyl-2-deoxy-β-D-thioglucopyranoside (CAS 4239-72-9)
- 2-(4-Amino-3-(difluoromethyl)-6-methylpyridin-2-yl)acetic acid (CAS 1805993-89-8)
- Mezlocillin Impurity 8 (CAS CATO-C4X-18318)
- 2,2,2-Trifluoroethyl 6-(3-methyl-1H-1,2,4-triazol-1-yl)nicotinate (CAS 400081-97-2)
- (2Z)-2-{[(4-chlorophenyl)amino]methylidene}-3-phenyl-2,3-dihydro-1H-inden-1-one (CAS 337921-23-0)
- D-Gln24-Tirzepatide (CAS CATO-CPTD788910)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com