N-(2-Chloro-6-fluorobenzyl)-N-methyl-2-(quinazolin-4-yloxy)acetamide CAS 852934-91-9
| CAS No. | 852934-91-9 |
| Molecular Formula | C18H15ClFN3O2 |
| Molecular Weight | 359.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 359.78 g/mol gives N-(2-Chloro-6-fluorobenzyl)-N-methyl-2-(quinazolin-4-yloxy)acetamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies N-(2-Chloro-6-fluorobenzyl)-N-methyl-2-(quinazolin-4-yloxy)acetamide (CAS 852934-91-9), a certified reference material (molecular formula C18H15ClFN3O2, MW 359.78 g/mol) for analytical method development and quality control.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, N-(2-Chloro-6-fluorobenzyl)-N-methyl-2-(quinazolin-4-yloxy)acetamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 359.78 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(2-Chloro-6-fluorobenzyl)-N-methyl-2-(quinazolin-4-yloxy)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15ClFN3O2 |
| Molecular Weight | 359.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- Methyl (4R)-4-(3-chloro-6-ethoxy-2-fluoro-5-((R)-1-hydroxyethyl)phenyl)-2-oxopyrrolidine-3-carboxylate (CAS 1995889-56-9)
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- 5-(3-Chlorophenoxy)-N-(4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-carboxamide (CAS 303997-93-5)
- 5-Amino-N-(4-chlorobenzyl)-1-(4-fluorobenzyl)-1H-1,2,3-triazole-4-carboxamide (CAS 899736-62-0)
- tert-Butyl (R)-3-((R)-(2-aminoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate (CAS 942142-78-1)
- N,2-Dibenzyl-4-(phenylsulfonyl)oxazol-5-amine (CAS 303753-61-9)
- 5-Bromo-8-nitroquinoline (CAS 176967-80-9)
- VE607, >98% (CAS 35058-81-2)
- Tiotropium impurity 48 (CAS CATO-C4X-176448)
- Pemirolast Impurity 3 (CAS CATO-C4X-24703)
- 4-(4-Ethyl-piperazin-1-yl)-phenol (CAS 1086392-78-0)
- (S)-(((2R,3R,4R,5R)-D-Sofosbuvir Isomer (CAS 1496552-28-3)
- 6-(Pent-4-ynyloxy)pyridine-3-carboximidamide (CAS 1987123-22-7)
- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
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