Tiotropium impurity 48 CAS CATO-C4X-176448
| CAS No. | CATO-C4X-176448 |
| Molecular Formula | C16H21NO4 |
| Molecular Weight | 291.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 291.34 g/mol gives Tiotropium impurity 48 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Tiotropium impurity 48 (CAS CATO-C4X-176448, C16H21NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tiotropium impurity 48 (C16H21NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tiotropium impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H21NO4 |
| Molecular Weight | 291.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Tiotropium Standards
- Tiotropium Bromide Impurity 14 (CAS 61616-97-5)
- Tiotropium Bromide Impurity 23 (CAS 54725-48-3)
- Tiotropium Impurity 41 (CAS CATO-C4X-176441)
- Tiotropium impurity 50 (CAS CATO-C4X-176450)
- Tiotropium impurity 42 (CAS 2512209-13-9)
- Tiotropium Bromide EP Impurity E; (CAS 26447-85-8)
- Tiotropium Impurity 27 (CAS 3140-93-0)
- Tiotropium EP Impurity A (CAS 4746-63-8)
Recommended Standards
- Roxatidine Impurity 41 (CAS CATO-C4X-121341)
- Etomidate impurity 55 (CAS CATO-C4X-188455)
- 2347AF 895261-67-3 C10H13NO5S2 Methyl 3-(morpholin-4-ylsulfonyl)thiophene-2-carboxylate (CAS 895261-67-3)
- Bisacodyl Impurity 18 (CAS 63019-58-9)
- Relugolix Impurity 80 (CAS CATO-C4X-242980)
- Orforglipron impurity 27 (CAS 465529-57-1)
- Brivaracetam Impurity 67 (CAS 357338-13-7)
- 2-(2-(Tert-butoxycarbonyl)tetrahydropyridazin-1(2H)-yl)-2-phenylacetic acid (CAS 952183-20-9)
- 4-(Trimethylsilyl)phenol (CAS 13132-25-7)
- 2-(2-Methoxyphenyl)benzo[d]thiazole (CAS 6269-47-2)
- Dapagliflozin Impurity 32 (CAS 2452300-89-7)
- Methyl Chloride (ca. 5.7% in Tetrahydrofuran, ca. 1mol/L) (CAS 74-87-3)
- (2-(4-Fluorophenyl)acetyl)glycine (CAS 10457-87-1)
- D-Gln24-Tirzepatide (CAS CATO-CPTD788910)
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