7-Chloro-2-((4-(4-hydroxyphenyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one CAS 854041-16-0
| CAS No. | 854041-16-0 |
| Molecular Formula | C19H19ClN4O2 |
| Molecular Weight | 370.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
7-Chloro-2-((4-(4-hydroxyphenyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one (CAS 854041-16-0), molecular formula C19H19ClN4O2 and molecular weight 370.83 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 7-Chloro-2-((4-(4-hydroxyphenyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one (C19H19ClN4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H19ClN4O2 |
| Molecular Weight | 370.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- 4-(4-Chlorophenyl)-1-(4-(2-fluorophenyl)thiazol-2-yl)-1H-pyrazol-5-amine (CAS 956193-95-6)
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- N-(3-(1H-imidazol-1-yl)propyl)-4-(2-(4-chlorophenyl)acetyl)-1H-pyrrole-2-carboxamide (CAS 478040-37-8)
- 3-((4-Chlorophenyl)diazenyl)-1-(morpholinomethyl)-1H-indol-2-ol (CAS 338391-71-2)
- 4-Chloro-8-methylquinolin-2-ol (CAS 113226-20-3)
- N-(2-(Furan-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-1-(thiophen-2-yl)cyclopentane-1-carboxamide (CAS 1207023-31-1)
- 4-(2-Nitrophenyl)-1h-pyrrole-3-carboxylic acid (CAS 1096868-11-9)
- 4-(Difluoromethyl)-5-methoxy-3-(trifluoromethoxy)picolinic acid (CAS 1805099-99-3)
- 4-Methyl-2-(piperidin-3-yl)pyrimidine (CAS 1316226-99-9)
- 4,7-Dibromo-3-iodo-1H-pyrrolo[3,2-c]pyridine (CAS 1000341-93-4)
- 2,4-Diaminoethylbenzene (CAS 1195-06-8)
- Ethyl 6-hydroxy-4-(4-methoxyphenyl)-2-phenyl-4,5-dihydropyrimidine-5-carboxylate (CAS 400078-30-0)
- Benzyl Glycolate (CAS 30379-58-9)
- Hepcidin/LEAP-1 (Human); Liver-Expressed Antimicrobial Peptide (CAS 342790-21-0)
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