4-Chloro-5-methylisoxazole-3-carboxamide CAS 85608-59-9
| CAS No. | 85608-59-9 |
| Molecular Formula | C5H5ClN2O2 |
| Molecular Weight | 160.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 160.56 g/mol gives 4-Chloro-5-methylisoxazole-3-carboxamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Chloro-5-methylisoxazole-3-carboxamide (CAS 85608-59-9), molecular formula C5H5ClN2O2 and molecular weight 160.56 g/mol, is a CATO reference standard with documented purity and traceability.
4-Chloro-5-methylisoxazole-3-carboxamide (C5H5ClN2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-5-methylisoxazole-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5ClN2O2 |
| Molecular Weight | 160.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-1h-pyrazole-3-carbohydrazide (CAS 1005584-54-2)
- 5-Chloro-2-methyl-1H-imidazole-4-carboxylic acid (CAS 1093261-72-3)
- 5-chloro-3-methyl-1H-pyrazole-4-carboxylic acid (CAS 1093414-62-0)
- 4-Chloro-6-methoxypyridazin-3(2H)-one (CAS 113707-82-7)
- 5-Chloro-6-methoxypyridazin-3(2H)-one (CAS 113707-83-8)
- 5-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid, 97% (CAS 1173246-76-8)
- Methyl 5-chloro-1H-imidazole-4-carboxylate (CAS 1192372-11-4)
- methyl 5-chloro-1H-imidazole-2-carboxylate (CAS 1211589-29-5)
Recommended Standards
- 4-Chloro-5-methyl-1H-pyrazole-3-carboxylic acid (CAS 29400-84-8)
- 4-Chloro-6-methoxy-1,3,5-triazin-2-amine (CAS 7254-11-7)
- 4-Chloro-5-methoxy-3(2H)-pyridazinone (CAS 63910-43-0)
- 4-Chloropyrazole-1-acetic Acid (CAS 32089-46-6)
- 2,4-Dibromo-3,6-dichloroaniline (CAS 27761-65-5)
- 3-bromo-2,6-dimethylaniline (CAS 53874-26-3)
- 6-Bromo-3-(difluoromethyl)-2-methoxypyridine (CAS 1805019-88-8)
- Hydroxychloroquine R-isomer Impurity (CAS 137433-23-9)
- 5-Fluoro-7-methyl-1H-indole (CAS 1082041-52-8)
- Tris[N,N-bis(trimethylsilyl)amide]thulium(III) (CAS 152763-53-6)
- 4-(3-((tert-Butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate (CAS 1253955-17-7)
- Disperse Orange 37 (CAS 13301-61-6)
- 2-[3-(propan-2-yl)-1H-1,2,4-triazol-5-yl]acetic acid (CAS 929339-46-8)
- Glucagon (19-29) (human, rat, porcine) (CAS 64790-15-4)
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