2-chloro-6-(trifluoromethyl)pyrimidin-4-amine CAS 85730-36-5
| CAS No. | 85730-36-5 |
| Molecular Formula | C5H9ClF3N3 |
| Molecular Weight | 203.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 203.59 g/mol gives 2-chloro-6-(trifluoromethyl)pyrimidin-4-amine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-chloro-6-(trifluoromethyl)pyrimidin-4-amine (CAS 85730-36-5) is a high-purity analytical reference standard with the molecular formula C5H9ClF3N3 and a molecular weight of 203.59 g/mol.
Owing to fluorine/chlorine substitution, 2-chloro-6-(trifluoromethyl)pyrimidin-4-amine is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 203.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-chloro-6-(trifluoromethyl)pyrimidin-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H9ClF3N3 |
| Molecular Weight | 203.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chloro Standards
- 2-chloro-N-ethyl-N-(2,2,2-trifluoroethyl)acetamide (CAS 1080474-99-2)
- 4-chloro-5-(trifluoromethyl)pyrimidin-2-amine (CAS 1201657-24-0)
- 2-chloro-4-(trifluoromethoxy)pyridine (CAS 1206975-33-8)
- 2-chloro-5-(trifluoromethyl)pyridin-4-ol (CAS 1211541-22-8)
- 6-chloro-4-(trifluoromethyl)pyridin-3-ol (CAS 1211578-60-7)
- 5-chloro-3-(trifluoromethyl)pyrazin-2-amine (CAS 1364663-32-0)
- 4-Chloro-2,6-dimethoxy-5-pyrimidinecarboxaldehyde-13C (CAS 1391054-67-3)
- 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine (CAS 1480-66-6)
Recommended Standards
- 2-chloro-6-(trifluoromethyl)pyridin-3-ol (CAS 731002-60-1)
- Ethyl 4-chloro-5-fluoronicotinate (CAS 1009334-54-6)
- 2-chloro-5-(trifluoromethyl)pyrimidin-4-amine (CAS 24101-09-5)
- 2-Amino-2-(3-chloro-5-fluorophenyl)acetic acid (CAS 1038843-45-6)
- Dimethyl 2-(2,2-dimethoxyethyl)malonate (CAS 51534-81-7)
- 2,6-Difluoro-3-(trifluoromethyl)phenol (CAS 2149589-77-3)
- N-(2-Acetylphenyl)methanesulfonamide (CAS 5317-80-6)
- 3-Bromo-7-methoxy-1H-pyrazolo[3,4-c]pyridine (CAS 1357946-82-7)
- (5-Methyl-1-propyl-1H-imidazol-2-yl)methanol (CAS 497855-85-3)
- 8-Isopropyl-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol (CAS 1453186-95-2)
- 1-(4-Nitrophenyl)-3-(piperidin-4-yl)urea hydrochloride (CAS 1233955-44-6)
- Prusogliptin Impurity 14 (CAS CATO-C4X-328414)
- Ethyl 5-bromo-3-methylpicolinate (CAS 794592-13-5)
- Tau Peptide (273-284) trifluoroacetate salt (CAS 1663490-91-2)
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