2,6-Difluoro-3-(trifluoromethyl)phenol CAS 2149589-77-3
| CAS No. | 2149589-77-3 |
| Molecular Formula | C7H3F5O |
| Molecular Weight | 198.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2,6-Difluoro-3-(trifluoromethyl)phenol is closely related to a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2,6-Difluoro-3-(trifluoromethyl)phenol (CAS 2149589-77-3) is a high-purity analytical reference standard with the molecular formula C7H3F5O and a molecular weight of 198.09 g/mol.
2,6-Difluoro-3-(trifluoromethyl)phenol (C7H3F5O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3F5O |
| Molecular Weight | 198.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 3,5-Difluoro-4-(trifluoromethyl)phenol (CAS 116640-11-0)
- 2,3-Difluoro-4-(trifluoromethyl)phenol (CAS 116640-12-1)
- 1,2-Difluoro-4-(trifluoromethoxy)benzene (CAS 1378671-81-8)
- 1,3-Difluoro-5-(trifluoromethoxy)benzene (CAS 1404194-50-8)
- 2,4-Difluoro-1-(trifluoromethoxy)benzene (CAS 1404194-72-4)
- 1,4-Difluoro-2-(trifluoromethoxy)benzene (CAS 1404195-06-7)
- 1,3-Difluoro-2-(trifluoromethoxy)benzene (CAS 153338-23-9)
- 1,2-Difluoro-3-(trifluoromethoxy)benzene (CAS 158178-35-9)
Recommended Standards
- 2,3,4,5,6-Pentafluoroanisole (CAS 389-40-2)
- 2,6-Difluoro-4-(trifluoromethyl)phenol (CAS 276244-25-8)
- 3,6-dichloro-N,N-dimethyl-pyridazin-4-amine (CAS 17258-35-4)
- 3,5-Difluoro-4-(trifluoromethyl)pyridin-2-amine (CAS 883498-68-8)
- Tetrahydro-2H-3,5-methanocyclopenta[b]furan-2,6(3H)-dione (CAS 16479-73-5)
- 4-((1-(5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yl)oxy)benzaldehyde, 97% (CAS 1254036-06-0)
- 1-(Pyrimidin-2-yl)cyclopentan-1-amine (CAS 1341558-23-3)
- Terpenylic Acid (CAS 116-51-8)
- 2-(4-Cyano-6-methoxypyridin-2-yl)acetic acid (CAS 1393539-83-7)
- Tetraethyl octane-1,8-diylbis(phosphonate) (CAS 5943-61-3)
- Benzyl 1H-indole-4-carboxylate (CAS 84401-11-6)
- 6-Bromo-1,4-dioxaspiro[4.4]non-6-ene (CAS 68241-78-1)
- (2S,3S,4S,5R)-2-Butoxy-2,5-bis(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 80971-59-1)
- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
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