1H-Indazole-4-sulfonyl chloride CAS 858227-51-7
| CAS No. | 858227-51-7 |
| Molecular Formula | C7H5ClN2O2S |
| Molecular Weight | 216.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1H-Indazole-4-sulfonyl chloride (CAS 858227-51-7) is a high-purity analytical reference standard with the molecular formula C7H5ClN2O2S and a molecular weight of 216.64 g/mol.
Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 1H-Indazole-4-sulfonyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 216.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClN2O2S |
| Molecular Weight | 216.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related H Standards
- 2H-Indazole-6-sulfonyl chloride (CAS 131290-01-2)
- 1H-Indazole-5-sulfonyl chloride (CAS 599183-35-4)
- 1H-indazole-6-carboxylic acid, 1-acetyl-, methyl ester (CAS 1027022-60-1)
- 1H-indazole-4-carboxylic acid, 1-acetyl-, methyl ester (CAS 1027991-36-1)
- (1h-Indazole-3-carbonyl)glycine (CAS 403483-02-3)
- Indazole Impurity 3 (CAS 1801267-04-8)
- 1H-indazole-5-carboxylic acid, 3-(Hydroxymethyl)-, methyl ester (CAS 1246250-09-8)
- 1H-Indazole-3,7-dicarboxylic acid (CAS 1427504-82-2)
Recommended Standards
- 1H-benzo[d]imidazole-2-sulfonyl chloride (CAS 59940-07-7)
- 1-(3-Chloro-5-fluoro-2-hydroxyphenyl)butan-1-one (CAS 2585-70-8)
- 2-(2-Chloro-4-fluorophenyl)-2-methylpropanoic acid (CAS 920501-64-0)
- (2-chloroimidazo[2,1-b][1,3]thiazol-6-yl)acetic acid,HCl (CAS 61984-80-3)
- 6-(Methylthio)pyrimidine-2,4-diamine (CAS 4765-71-3)
- 6-Chloro-3-iodo-8-methylimidazo[1,2-a]pyrazine (CAS 1823381-40-3)
- 4-((6-Amino-2-(2-methoxyethoxy)-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl)benzonitrile (CAS 1096159-02-2)
- 3-Amino-2-ethoxypyridine (CAS 51468-01-0)
- Methyl 3-bromo-2,6-dichlorobenzoate (CAS 232277-30-4)
- 3-(Trifluoromethyl)pyridine-2-sulfonamide (CAS 104040-76-8)
- N-((5-Cyclopropyl-1-methyl-1H-pyrazol-3-yl)methyl)-1-(thiophen-2-yl)cyclopentane-1-carboxamide (CAS 1448072-26-1)
- Isopropyl (1S,3S)-3-hydroxycyclohexane-1-carboxylate (CAS 99438-50-3)
- 2-(3-Bromo-2-fluoro-6-nitrophenyl)acetic acid (CAS 1807155-75-4)
- Serpent Peptide 2AcOH (CAS 823202-99-9(free base))
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