Naphazoline EP Impurity B CAS 86-87-3
| CAS No. | 86-87-3 |
| Molecular Formula | C12H10O2 |
| Molecular Weight | 186.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Naphazoline EP Impurity B (CAS 86-87-3, C12H10O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Naphazoline EP Impurity B (C12H10O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10O2 |
| Molecular Weight | 186.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Naphazoline Standards
- Naphazoline Impurity 6 (CAS 36660-46-5)
- Naphazoline Impurity 1 (CAS 17518-47-7)
- Naphazoline EP Impurity C (CAS 132-75-2)
- Naphazoline Impurity 2 (CAS 1019-21-2)
- Naphazoline EP Impurity D (CAS 22126-67-6)
- Naphazoline (CAS 835-31-4)
- Naphazoline EP Impurity A (CAS 36321-43-4)
- Naphazoline impurity 7 (CAS CATO-C4X-14407)
Recommended Standards
- Domperidone Impurity 19 (CAS 53786-42-8)
- Gabapentin EP Impurity E (CAS 67950-95-2)
- Nafamostat impurity 127 (CAS CATO-C4X-1332127)
- Tranexamic Impurity 25 (CAS CATO-C4X-177125)
- Dorzolamide Impurity 2 (CAS 147128-77-6)
- Doxycycline EP Impurity C（HCl） (CAS CATO-C4X-193114)
- Azilsartan Impurity 78 (CAS CATO-C4X-109678)
- Betaquiline Impurity 24 (CAS CATO-C4X-116724)
- 2-Cyclopropylaniline (CAS 3158-73-4)
- 5-Bromo-2-methylaniline hydrochloride (CAS 874375-16-3)
- Pramipexole Impurity 92 (CAS 90978-87-3)
- (2S,4S)-1-(tert-Butoxycarbonyl)-4-(2-ethylphenoxy)-2-pyrrolidinecarboxylic acid (CAS 869682-00-8)
- 5-((tert-Butyldimethylsilyl)oxy)-2-methylpyridine (CAS 215232-65-8)
- Semaglutide impurity 286 (CAS CATO-C4X-2226286)
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