5-(4-Fluorophenyl)-6-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile CAS 860611-66-1
| CAS No. | 860611-66-1 |
| Molecular Formula | C19H18FN5O |
| Molecular Weight | 351.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-(4-Fluorophenyl)-6-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (C19H18FN5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
5-(4-Fluorophenyl)-6-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (CAS 860611-66-1), molecular formula C19H18FN5O and molecular weight 351.38 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H18FN5O |
| Molecular Weight | 351.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Fluorophenyl Standards
- (4-(4-Fluorophenyl)-1H-pyrrol-2-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone (CAS 1219845-17-6)
- 7-(4-Fluorophenyl)-2-(methylsulfonyl)thieno[3,2-d]pyrimidine-6-carboxamide (CAS 1462949-98-9)
- (3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)(morpholino)methanone (CAS 380463-06-9)
- 1-(4-(2-Fluorophenyl)piperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione (CAS 852367-22-7)
- 3-(4-Fluorophenyl)-5-((4-(p-tolyl)thiazol-2-yl)methyl)-1,2,4-oxadiazole (CAS 1112280-09-7)
- 4-(1-(4-Fluorophenyl)-1H-pyrazol-4-yl)-N-(thiophen-3-ylmethyl)pyrimidin-2-amine (CAS 1227707-44-9)
- 4-(4-Fluorophenyl)-5-((naphthalen-1-yloxy)methyl)-4H-1,2,4-triazole-3-thiol (CAS 917746-74-8)
- 5-(3-(4-Fluorophenyl)ureido)-N,N,2-trimethylbenzenesulfonamide (CAS 380320-85-4)
Recommended Standards
- 4-[5-amino-4-(1,3-benzothiazol-2-yl)-3-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid (CAS 610278-84-7)
- 7-Hydroxy-3-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-2H-chromen-2-one (CAS 304881-10-5)
- 3-[5-Amino-4-(2-benzothiazolyl)-2,3-dihydro-3-oxo-1H-pyrrol-1-yl]benzoic acid (CAS 379726-61-1)
- 8-Oxo-2-(thiophen-2-yl)-9-(p-tolyl)-8,9-dihydro-7H-purine-6-carboxamide (CAS 863502-35-6)
- 2-Bromo-3-chloro-4-cyanobenzoic acid (CAS 1805576-52-6)
- (1-(2-Fluorophenyl)-1h-1,2,3-triazol-4-yl)methanamine (CAS 1250180-52-9)
- H-Gly-Phe-OH (CAS 3321-03-7)
- Prasugrel Impurity 39 (CAS 866761-68-4)
- 2-Bromo-6-methylbenzenethiol (CAS 1349708-74-2)
- Cisanilide (CAS 34484-77-0)
- 2-Pyridin-4-yl-1H-benzimidazole (CAS 2208-59-5)
- 4-iodo-1-N-methylbenzene-1,2-diamine dihydrochloride (CAS 1864073-55-1)
- Nonyl Chloroformate (CAS 57045-82-6)
- (Ser(PO?H?)3??·???)-Tau Peptide (379-408) trifluoroacetate salt (CAS 2022956-60-9)
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