N-(4-chlorophenyl)-2,2,2-trifluoro-N-(4-methoxybenzyl)acetamide CAS 860649-56-5

Purity 97%+In StockPharmaceutical Standards
CAS No.860649-56-5
Molecular FormulaC16H13ClF3NO2
Molecular Weight343.73 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

N-(4-chlorophenyl)-2,2,2-trifluoro-N-(4-methoxybenzyl)acetamide CAS 860649-56-5 chemical structure

Description

The molecular framework of N-(4-chlorophenyl)-2,2,2-trifluoro-N-(4-methoxybenzyl)acetamide (C16H13ClF3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

N-(4-chlorophenyl)-2,2,2-trifluoro-N-(4-methoxybenzyl)acetamide (CAS 860649-56-5) is a high-purity analytical reference standard with the molecular formula C16H13ClF3NO2 and a molecular weight of 343.73 g/mol.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), N-(4-chlorophenyl)-2,2,2-trifluoro-N-(4-methoxybenzyl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC16H13ClF3NO2
Molecular Weight343.73 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1987
Halogen ContentF/Cl-containing
Nitrogen Atoms1

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