Efavirenz Impurity 26 CAS 2177283-35-9
| CAS No. | 2177283-35-9 |
| Molecular Formula | C16H13ClF3NO2 |
| Molecular Weight | 343.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Efavirenz Impurity 26 (C16H13ClF3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Efavirenz Impurity 26 (CAS 2177283-35-9) is a certified pharmaceutical impurity reference standard with the molecular formula C16H13ClF3NO2 and a molecular weight of 343.73 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Efavirenz Impurity 26 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H13ClF3NO2 |
| Molecular Weight | 343.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz RC 2 (CAS 173676-54-5)
- Efavirenz Impurity 27 (CAS CATO-C4X-162727)
- Efavirenz Impurity 8 (CAS 211563-40-5)
- Efavirenz Impurity (6-chloro-4-[2-(2-methylcyclopropyl)ethynyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) (CAS 1217623-65-8)
- Efavirenz Impurity 7 (CAS 211563-41-6)
- Efavirenz-13C6 (CAS 1261394-62-0)
- rac Efavirenz-d5(major) (CAS 1132642-95-5)
- rac Efavirenz-d4 (CAS 1246812-58-7)
Recommended Standards
- N1-[4-(tert-butyl)phenyl]-3-[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]acrylamide (CAS 648859-64-7)
- 4-Chloro-N-(6-methoxypyridin-3-yl)-2-nitrobenzenesulfonamide (CAS 1022580-32-0)
- N-(4-chlorophenyl)-2,2,2-trifluoro-N-(4-methoxybenzyl)acetamide (CAS 860649-56-5)
- 4-Chloro-N-(4-fluorophenyl)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxamide (CAS 339031-72-0)
- Meropenem impurity 29 (CAS CATO-C4X-130929)
- Entacapone Impurity 28 (CAS 2450-26-2)
- Norepinephrine Impurity 156 (CAS CATO-C4X-1514156)
- 2-(Methoxymethoxy)benzoic Acid 5876-91-5 o-(Methoxymethoxy)benzoic Acid (CAS 5876-91-5)
- 3-(Ethoxymethyl)-4-methoxybenzaldehyde (CAS 832737-85-6)
- (2,6-Dimethoxyphenyl)(quinolin-3-yl)methanone (CAS 1187163-88-7)
- 1h,2h-Pyrrolo[1,2-d][1,2,4]triazin-1-one (CAS 50269-86-8)
- Pramipexole Impurity 73 (CAS 3028194-78-4(free base))
- 2-(Hydroxymethyl)azetidine-1-carboxylic acid (CAS 1807542-91-1)
- Semaglutide Impurity 192 (CAS CATO-C4X-2226192)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com