Fruquintinib Impurity 4 CAS 860749-26-4
| CAS No. | 860749-26-4 |
| Molecular Formula | C18H18N2O8 |
| Molecular Weight | 390.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Fruquintinib Impurity 4 (C18H18N2O8) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Fruquintinib Impurity 4 (CAS 860749-26-4) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18N2O8 and a molecular weight of 390.34 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Fruquintinib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18N2O8 |
| Molecular Weight | 390.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Fruquintinib Standards
- Fruquintinib impurity 7 (CAS CATO-C4X-30377)
- Fruquintinib Impurity 5 (CAS CATO-C4X-30375)
- Fruquintinib (CAS 1194506-26-7)
- Fruquintinib Impurity 10 (CAS CATO-C4X-303710)
- Fruquintinib Impurity 8 (CAS CATO-C4X-30378)
- Fruquintinib Impurity 6 (CAS CATO-C4X-30376)
- Fruquintinib-d6 (CAS 2978508-76-6)
- Fruquintinib Impurity 14 (CAS CATO-C4X-303714)
Recommended Standards
- Ketotifen Impurity 21 (CAS CATO-C4X-204621)
- Nicardipine Impurity 34 (CAS CATO-C4X-171034)
- 1,2,3,4,6-O-Pentaacetyl-alpha-mannose (CAS 4163-65-9)
- Dapagliflozin Impurity 76 (CAS 604-69-3)
- Benidipine Impurity 76 (CAS CATO-C4X-112076)
- Samidorphan Impurity 12 (CAS CATO-C4X-330912)
- Losartan EP Impurity C(Potassium Salt) (CAS 860644-28-6)
- 3,5,5-trimethylpiperidin-2-one (CAS 1461709-34-1)
- N-(5,6,7,8-Tetrahydroquinolin-4-yl)acetamide (CAS 858466-68-9)
- 622-60-6 Benzene, 1-ethoxy-4-methyl- 4-Methylphenetole Phenetole, p-methyl- (8CI) AI3-24341 EINECS 210-746-0 1-Ethoxy-4-methylbenzene p-Ethoxytoluene Ethyl p-tolyl ether p-Methylphenetole NSC 6259 (CAS 622-60-6)
- Anion Standard - Nitrite (CAS 14797-65-0)
- 3-(3-Formyl-4-hydroxyphenyl)propanoic acid (CAS 99059-14-0)
- (11bR)-N-Benzyl-N,2,6-trimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine (CAS 883229-45-6)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
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