Thiamine Impurity 33 CAS 861031-76-7
| CAS No. | 861031-76-7 |
| Molecular Formula | C8H14N4 |
| Molecular Weight | 166.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, Thiamine Impurity 33 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 166.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Thiamine Impurity 33 (CAS 861031-76-7, C8H14N4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H14N4 |
| Molecular Weight | 166.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 4 |
Related Thiamine Standards
- Thiamine Impurity 37 (CAS 1698838-89-9)
- Thiamine Impurity 38 (CAS 1199782-58-5)
- Thiamine /Vitamin B1 Impurity 18 (CAS 1886-34-6)
- Thiamine Impurity 17 (CAS 73-66-5)
- Thiamine Impurity 11 (CAS 189745-28-6)
- Thiamine Impurity 54 (CAS 1124-01-2)
- Thiamine Impurity 2 (CAS 769-82-4)
- Thiamine Impurity N1 (CAS 7403-34-1)
Recommended Standards
- Cefmetazole Impurity 58 (CAS CATO-C4X-150758)
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- Latanoprost Impurity 23 (CAS 124988-64-3)
- Remdesivir Impurity 16 (CAS CATO-C4X-210016)
- Meropenem Impurity 33 (CAS CATO-C4X-130933)
- Cefdinir Impurity 6 (CAS 79350-14-4)
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