2-(2-Chlorothiazol-5-yl)acetonitrile CAS 865660-15-7
| CAS No. | 865660-15-7 |
| Molecular Formula | C5H3ClN2S |
| Molecular Weight | 158.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(2-Chlorothiazol-5-yl)acetonitrile (CAS 865660-15-7) is a high-purity analytical reference standard with the molecular formula C5H3ClN2S and a molecular weight of 158.61 g/mol.
The molecular framework of 2-(2-Chlorothiazol-5-yl)acetonitrile (C5H3ClN2S) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-(2-Chlorothiazol-5-yl)acetonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H3ClN2S |
| Molecular Weight | 158.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chlorothiazol Standards
- 2-(4-Chlorothiazol-2-yl)acetonitrile (CAS 1433708-74-7)
- 1-(2-Chlorothiazol-4-yl)ethan-1-one (CAS 222169-08-6)
- 2-(2-Chlorothiazol-5-yl)acetaldehyde (CAS 214545-44-5)
- 1-(5-Chlorothiazol-2-yl)ethan-1-amine (CAS 1501932-79-1)
- 1-(2-Chlorothiazol-4-yl)-N-methylmethanamine (CAS 1934803-58-3)
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- 1-(5-Chlorothiazol-2-yl)ethan-1-ol (CAS 1514403-05-4)
- 2-(2-Chlorothiazol-5-yl)ethan-1-ol (CAS 1783503-14-9)
Recommended Standards
- 2-Amino-4-chlorothiophene-3-carbonitrile (CAS 90312-20-2)
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- 4-Amino-5-chlorothiophene-2-carbonitrile (CAS 1369166-92-6)
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- 4-Chloro-5-(difluoromethyl)-3-iodopyridine-2-sulfonamide (CAS 1804494-68-5)
- Acetyl Tetrapeptide- 15 (CAS 928007-64-1)
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