N-(3-chloro-4-methoxybenzyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide CAS 866137-31-7
| CAS No. | 866137-31-7 |
| Molecular Formula | C19H19Cl2F3N4O2 |
| Molecular Weight | 463.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-(3-chloro-4-methoxybenzyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide (C19H19Cl2F3N4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
N-(3-chloro-4-methoxybenzyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide (CAS 866137-31-7), molecular formula C19H19Cl2F3N4O2 and molecular weight 463.28 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures N-(3-chloro-4-methoxybenzyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H19Cl2F3N4O2 |
| Molecular Weight | 463.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- 4-Chloro-N-[2-(6-chloro-4-trifluoromethyl-pyridine-2-sulfonyl)-ethyl]-benzenesulfonamide (CAS 1311278-04-2)
- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-N-(4-chlorophenyl)benzene-1-sulfonamide (CAS 338775-30-7)
- 2-{[5-chloro-1-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazin-4-yl](methyl)amino}ethyl N-(4-chlorophenyl)carbamate (CAS 477867-37-1)
- 2-Chloro-N-(2-chlorophenyl)-5-(2-(1-(pyridin-4-yl)ethylidene)hydrazine-1-carbonyl)benzenesulfonamide (CAS 731826-86-1)
- Chloro(crotyl)[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(II) (CAS 1334497-06-1)
- 2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)amino}ethan-1-ol (CAS 190437-61-7)
- 5-Chloro-3-{[(4-chlorophenyl)sulfanyl]methyl}-1-methyl-4-({[3-(trifluoromethyl)phenyl]sulfanyl}methyl)-1H-pyrazole (CAS 318234-42-3)
- (5-Chloro-2-phenoxyphenyl)triphenylsilane (CAS 18866-43-8)
Recommended Standards
- 4-((2,6-Dichlorobenzyl)oxy)-2-(3-(trifluoromethyl)benzyl)quinazoline (CAS 861208-35-7)
- Tepotinib impurity 13 (CAS CATO-C4X-337413)
- 1-(2,4-Difluorophenyl)-6-oxo-4-(trifluoromethyl)-N-(4-(trifluoromethyl)phenyl)-1,6-dihydropyridazine-3-carboxamide (CAS 477859-68-0)
- HA 150 (CAS 1229652-21-4)
- AM 8553 (CAS 1352064-70-0)
- Phenolphthalein anilide (CAS 6607-41-6)
- (4S)-5,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride (CAS 1807940-80-2)
- 4,5,6-Trimethylpicolinic acid (CAS 1261269-42-4)
- Tert-butyl 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-3-yl)morpholine-4-carboxylate (CAS 2223003-47-0)
- 2-methyl-2,3-dihydro-1,4-benzodioxine-2-carbonyl chloride (CAS 77156-57-1)
- 5-Chloropicolinic Acid (CAS 86873-60-1)
- 2-(Difluoromethyl)-4-fluoro-3-methoxypyridine-6-carbonyl chloride (CAS 1805605-94-0)
- 3-(Adamantan-1-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde (CAS 401632-70-0)
- [β-Asp]9-Semaglutide (CAS CATO-CPTD788605)
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