2-(4-Nitrophenyl)-N'-[(1E)-{1-[4-(trifluoromethoxy)phenyl]-1H-pyrrol-2-yl}methylidene]propanehydrazide CAS 866144-57-2
| CAS No. | 866144-57-2 |
| Molecular Formula | C21H17F3N4O4 |
| Molecular Weight | 446.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(4-Nitrophenyl)-N'-[(1E)-{1-[4-(trifluoromethoxy)phenyl]-1H-pyrrol-2-yl}methylidene]propanehydrazide is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(4-Nitrophenyl)-N'-[(1E)-{1-[4-(trifluoromethoxy)phenyl]-1H-pyrrol-2-yl}methylidene]propanehydrazide (CAS 866144-57-2), molecular formula C21H17F3N4O4 and molecular weight 446.38 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2-(4-Nitrophenyl)-N'-[(1E)-{1-[4-(trifluoromethoxy)phenyl]-1H-pyrrol-2-yl}methylidene]propanehydrazide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 446.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H17F3N4O4 |
| Molecular Weight | 446.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Nitrophenyl Standards
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- 2-(3-Nitrophenyl)-2-oxoethyl 6-chloro-2-phenylquinoline-4-carboxylate (CAS 355420-42-7)
- N-(4-nitrophenyl)-2-((4-phenyl-5-(m-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 505065-03-2)
- 1-(4-Nitrophenyl)-2,5,6-triphenylpyrimidin-4(1H)-one (CAS 88317-18-4)
- 2-(4-Nitrophenyl)-1,5,6-triphenylpyrimidin-4(1H)-one (CAS 88317-21-9)
- 4-Nitrophenyl 2-O-(b-L-fucopyranosyl)-β-D-galactopyranoside (CAS 77640-21-2)
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Recommended Standards
- Ramelteon RC 8 (CAS 1246820-32-5)
- 4-{[(4-bromophenyl)sulfanyl]methyl}-1-[(4-methylphenyl)sulfanyl]-2-nitrobenzene (CAS 477869-74-2)
- Aripiprazole EP Impurity E (CAS 129722-25-4)
- Sorafenib Impurity 38 (CAS 862875-16-9)
- 4-(2,4-Difluorophenyl)butan-1-amine (CAS 1344317-44-7)
- 2-Methylpent-3-yn-2-amine hydrochloride (CAS 5933-08-4)
- (Z)-N-(1-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)imidazolidin-2-ylidene)nitramide (CAS 1781254-33-8)
- Ruxolitinib Impurity 76 (CAS CATO-C4X-205876)
- 2,6-Diisopropylphenylimidoneophylidene molybdenum(VI) bis(hexafluoro-t-butoxide) (CAS 139220-25-0)
- Tocrifluor T1117 (CAS 1186195-59-4)
- Bortezomib Impurity 56 TFA salt (CAS CATO-C4X-107256)
- 3-((5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)benzoic acid (CAS 919278-71-0)
- 2-(2-Methylenebutyl)cyclopentan-1-ol (CAS 1480552-97-3)
- Tirzepatide Impurity 21 X TFA Salt (CAS CATO-C4X-324021)
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