Sorafenib Impurity 38 CAS 862875-16-9
| CAS No. | 862875-16-9 |
| Molecular Formula | C21H17F3N4O4 |
| Molecular Weight | 446.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 446.38 g/mol gives Sorafenib Impurity 38 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Sorafenib Impurity 38 (CAS 862875-16-9), a pharmacopoeial impurity reference standard (molecular formula C21H17F3N4O4, MW 446.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Sorafenib Impurity 38 (C21H17F3N4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 446.38 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sorafenib Impurity 38 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H17F3N4O4 |
| Molecular Weight | 446.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sorafenib Standards
- Sorafenib Impurity 18 (CAS 284461-74-1)
- Sorafenib Impurity 16 (CAS 1012058-78-4)
- Sorafenib EP Impurity F (CAS 1285533-84-7)
- Sorafenib (Base) (CAS 284461-73-0)
- Sorafenib Impurity 40 (CAS 1290546-48-3)
- Sorafenib Impurity 42 (CAS CATO-C4X-112442)
- Sorafenib EP Impurity H (CAS 1431697-81-2)
- Sorafenib related compound 26 (CAS 573673-43-5)
Recommended Standards
- 4-{[(4-bromophenyl)sulfanyl]methyl}-1-[(4-methylphenyl)sulfanyl]-2-nitrobenzene (CAS 477869-74-2)
- Tosufloxacin Impurity 3 (CAS CATO-C4X-19763)
- 2-(4-Nitrophenyl)-N'-[(1E)-{1-[4-(trifluoromethoxy)phenyl]-1H-pyrrol-2-yl}methylidene]propanehydrazide (CAS 866144-57-2)
- 1,1'-Bis(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]-1,1'-diium (CAS 2639670-64-5)
- Teneligliptin impurity 35 (CAS CATO-C4X-176035)
- Betamethasone Impurity 141 (CAS CATO-C4X-1437141)
- Glycerol Impurity 32 (CAS CATO-C4X-217132)
- 4-Hydroxy-3-(trifluoromethyl)benzonitrile (CAS 124811-71-8)
- 3-Benzylbenzo[d][1,2,3]triazin-4(3H)-one (CAS 15561-72-5)
- n-(3-Aminopropyl)-N-methylcyclobutanecarboxamide (CAS 1019448-01-1)
- 3-(4-Ethylpiperazin-1-yl)propanoic acid dihydrochloride (CAS 1185303-69-8)
- 5-Amino-1-(pyridin-2-yl)-2,3-dihydro-1H-pyrazol-3-one (CAS 126583-28-6)
- Methyl (E)-3-(4-Chloro-3-nitrophenyl)acrylate (CAS 877065-30-0)
- Semaglutide impurity 214 (CAS CATO-C4X-2226214)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com