(4-((4-Fluorophenyl)sulfonyl)piperazin-1-yl)(3-(trifluoromethyl)phenyl)methanone CAS 866152-65-0
| CAS No. | 866152-65-0 |
| Molecular Formula | C18H16F4N2O3S |
| Molecular Weight | 416.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (4-((4-Fluorophenyl)sulfonyl)piperazin-1-yl)(3-(trifluoromethyl)phenyl)methanone.
(4-((4-Fluorophenyl)sulfonyl)piperazin-1-yl)(3-(trifluoromethyl)phenyl)methanone (CAS 866152-65-0) is a high-purity analytical reference standard with the molecular formula C18H16F4N2O3S and a molecular weight of 416.39 g/mol.
The molecular framework of (4-((4-Fluorophenyl)sulfonyl)piperazin-1-yl)(3-(trifluoromethyl)phenyl)methanone (C18H16F4N2O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H16F4N2O3S |
| Molecular Weight | 416.39 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Fluorophenyl Standards
- 1-((4-Fluorophenyl)sulfonyl)-N-(3-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide (CAS 317377-86-9)
- 1-[(2-Fluorophenyl)methyl]-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea (CAS 1796898-53-7)
- 1-[(3-Fluorophenyl)methyl]-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea (CAS 1796915-83-7)
- 5-(2-Fluorophenyl)-3-hydroxy-1-(2-morpholinoethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one (CAS 381188-66-5)
- 1-(2-Fluorophenyl)-4-{[2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl]methyl}piperazine (CAS 338415-61-5)
- N-(5-((2-((4-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-phenylpropanamide (CAS 477212-96-7)
- 4-(2-((6-(2-(4-Fluorophenyl)-4-methylthiazol-5-yl)pyridazin-3-yl)thio)ethyl)morpholine (CAS 1005296-96-7)
- 2-(4-Fluorophenyl)-6-methoxyquinoline-4-carboxylic acid (CAS 18060-41-8)
Recommended Standards
- (2R,3S,5R)-5-(2-Amino-6-(4-nitrophenethoxy)-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 86137-72-6)
- 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone (CAS 1071454-96-0)
- 2-(4-Nitrophenoxy)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide (CAS 89632-45-1)
- Chrysophanol-8-O-β-D-glucopyranoside (CAS 13241-28-6)
- 3-Amino-1-[(4-methoxyphenyl)methyl]pyrrolidin-2-one (CAS 1248990-38-6)
- N-((1-Benzylpiperidin-2-yl)methyl)-2-chloro-N-cyclopropylacetamide (CAS 1353984-45-8)
- Tert-butyl (S)-3-(1-amino-2-hydroxyethyl)azetidine-1-carboxylate (CAS 2227897-93-8)
- tert-Butyl 2,2-dimethyl-5-(6-phenoxynaphthalen-2-yl)-1,3-dioxan-5-ylcarbamate (CAS 1206676-76-7)
- 4-(3-Phenyl-5-(p-tolyl)-1H-pyrazol-1-yl)benzenesulfonamide (CAS 111607-61-5)
- 1-(3,4-Difluorobenzyl)-1H-imidazole (CAS 906478-71-5)
- 2-(2-Methoxyphenoxy)-1-(4-(thiophen-3-yl)piperidin-1-yl)ethan-1-one (CAS 1421531-06-7)
- Avibactam Impurity N31 (CAS 396731-20-7)
- HJC 0350 (CAS 885434-70-8)
- Ephrin-A2-Selective YSA-Peptide (CAS 532441-10-4)
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