1-(3,4-Difluorobenzyl)-1H-imidazole CAS 906478-71-5
| CAS No. | 906478-71-5 |
| Molecular Formula | C10H8F2N2 |
| Molecular Weight | 194.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(3,4-Difluorobenzyl)-1H-imidazole (CAS 906478-71-5), molecular formula C10H8F2N2 and molecular weight 194.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(3,4-Difluorobenzyl)-1H-imidazole (C10H8F2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8F2N2 |
| Molecular Weight | 194.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorobenzyl Standards
- 1-(2,4-Difluorobenzyl)-1H-imidazole (CAS 1340454-54-7)
- 1-(2,5-Difluorobenzyl)-1H-imidazole (CAS 1342052-35-0)
- 1-(2,6-Difluorobenzyl)-1H-imidazole (CAS 1378819-89-6)
- 1-(3,5-Difluorobenzyl)-1H-imidazole (CAS 170166-01-5)
- 1-(3,4-Difluorobenzyl)-1H-pyrrole (CAS 1247669-63-1)
- N-(2,5-difluorobenzyl)acrylamide (CAS 1342290-81-6)
- 3-(2,5-Difluorobenzyl)pyrrolidine (CAS 1100640-03-6)
- (S)-2-(3,4-difluorobenzyl)pyrrolidine (CAS 1232829-80-9)
Recommended Standards
- 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-hydroxyethanone (CAS 583860-52-0)
- 1-(6,7-Dihydroxy-2,3-dihydrobenzofuran-5-yl)ethanone (CAS 88897-93-2)
- [2,2'-Bifuran]-5,5'-diyldimethanol (CAS 50738-84-6)
- 1-(Difluoromethoxy)naphthalene (CAS 920981-10-8)
- Methyl 5-bromo-4-trifluoromethyl-thiazole-2-carboxylate (CAS 79247-83-9)
- 4-Ethynyl-2,5-dimethoxybenzaldehyde (CAS 1208264-50-9)
- 2-Methyl-N-((5-methylthiophen-2-yl)methyl)butan-2-amine (CAS 931991-38-7)
- 5-Methoxy-2-((p-tolylthio)methyl)-4H-pyran-4-one (CAS 1949836-81-0)
- Ethyl 2-(5-chloro-6-fluoropyridin-3-yl)acetate (CAS 1393557-23-7)
- 3-Methoxy-4-((5-methylisoxazol-3-yl)methoxy)benzonitrile (CAS 876388-15-7)
- Cefuroxime Impurity 45 (CAS 80154-48-9)
- Mavacamten-D5 (CAS 2453251-00-6)
- Phallacidin (CAS 26645-35-2)
- Semaglutide impurity 77 (CAS CATO-C4X-222677)
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