4-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-3,4-dihydro-2H-1-benzopyran CAS 866155-72-8
| CAS No. | 866155-72-8 |
| Molecular Formula | C18H14F6O2 |
| Molecular Weight | 376.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 4-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-3,4-dihydro-2H-1-benzopyran (CAS 866155-72-8), a certified reference material (molecular formula C18H14F6O2, MW 376.29 g/mol) for analytical method development and quality control.
Owing to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution, 4-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-3,4-dihydro-2H-1-benzopyran is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 376.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H14F6O2 |
| Molecular Weight | 376.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related bis Standards
- N'-{4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoyl}benzohydrazide (CAS 1803605-08-4)
- 5-({2-[3-(Trifluoromethyl)phenoxy]phenyl}methylene)-2,4,6(1H,3H,5H)-pyrimidinetrione (CAS 477857-04-8)
- 1,4-Bis(5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 131136-84-0)
- Ethyl 3-(3-(trifluoromethyl)benzamido)-1H-indole-2-carboxylate (CAS 338968-28-8)
- 2-Phenyl-4-((3-(trifluoromethyl)phenyl)thio)pyrimidine-5-carboxylic acid (CAS 477854-57-2)
- N-(2-(2-(4-(Trifluoromethyl)phenyl)thiazol-4-yl)ethyl)benzamide (CAS 896679-26-8)
- 1'-Benzyl-7-(trifluoromethyl)-4,5-dihydro-3H-spiro[benzo[b][1,4]oxazepine-2,4'-piperidine] (CAS 1956331-99-9)
- 5-((4-(Trifluoromethyl)benzyl)thio)imidazo[1,2-c]quinazolin-2(3H)-one (CAS 478046-12-7)
Recommended Standards
- 4-(1H-imidazol-1-yl)-3-nitro-N-(3-(trifluoromethyl)phenyl)benzamide (CAS 400079-12-1)
- 3-Nitro-4-(1H-pyrazol-1-yl)-N-[3-(trifluoromethyl)phenyl]benzenecarboxamide (CAS 321534-59-2)
- N-(4-Bromo-2-isopropylphenyl)-2-(4-ethylphenoxy)acetamide (CAS 528531-90-0)
- 3-(5-(4-Bromophenyl)furan-2-yl)-N-cyclohexylpropanamide (CAS 853331-22-3)
- 1-Iodo-2-(methoxymethoxy)benzene (CAS 80778-47-8)
- 2-Fluoro-2-(p-tolyl)acetic acid (CAS 175845-89-3)
- (Z)-1-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)pyridin-2-yl)ethan-1-one O-(4-chlorobenzoyl) oxime (CAS 860611-43-4)
- 2-(Difluoromethyl)pyrimidine-5-carboxylic acid (CAS 1260902-00-8)
- 3-(3'-Methoxy-[1,1'-biphenyl]-4-yl)propanoic acid (CAS 893641-26-4)
- Granisetron Impurity 14 (CAS CATO-C4X-197014)
- Indacaterol Impurity 37 (CAS CATO-C4X-150037)
- (S)-3-Amino-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester hydrochloride (CAS 2305080-42-4)
- (SP-5-41)-Dichloro[1-(2,6-diethylphenyl)-3,3-dimethyl-5-(1-methylethyl)-2-pyrrolidinylidene][[2-(1-methylethoxy-κO)phenyl]methylene-κC]ruthenium (CAS 1459791-98-0)
- Semaglutide impurity 98 (CAS CATO-C4X-222698)
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