(E)-2-Cyano-3-(4-ethoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-2-propenamide CAS 866156-41-4
| CAS No. | 866156-41-4 |
| Molecular Formula | C19H15F3N2O2 |
| Molecular Weight | 360.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (E)-2-Cyano-3-(4-ethoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-2-propenamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies (E)-2-Cyano-3-(4-ethoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-2-propenamide (CAS 866156-41-4), a certified reference material (molecular formula C19H15F3N2O2, MW 360.33 g/mol) for analytical method development and quality control.
The molecular framework of (E)-2-Cyano-3-(4-ethoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-2-propenamide (C19H15F3N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-2-Cyano-3-(4-ethoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-2-propenamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H15F3N2O2 |
| Molecular Weight | 360.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related E Standards
- N-(2-((3-Cyano-6-methylquinolin-2-yl)amino)ethyl)-2-methoxybenzamide (CAS 606105-50-4)
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- N-(2-((3-Cyano-8-methylquinolin-2-yl)amino)ethyl)-2-methoxybenzamide (CAS 606105-14-0)
- N-(2-((3-Cyano-8-methylquinolin-2-yl)amino)ethyl)-3-methoxybenzamide (CAS 606104-84-1)
- Ethyl 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate (CAS 1572503-72-0)
- Ethyl 5-cyano-2-phenyl-6-(phenylsulfanyl)pyridine-3-carboxylate (CAS 306980-00-7)
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Recommended Standards
- 1-(4-Aminobenzyl)-N-(3-(trifluoromethyl)phenyl)-1H-imidazole-4-carboxamide (CAS 1351827-63-8)
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- 4-[4-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-pyrimidin-2-ol (CAS 1311279-78-3)
- (Z)-1-(3-morpholino-5-(trifluoromethyl)pyridin-2-yl)ethan-1-one O-dimethylcarbamoyl oxime (CAS 860650-98-2)
- Ethyl 3-nitroacrylate (CAS 1851-82-7)
- N-(2,2-difluoroethyl)-1-methylpiperidin-4-amine (CAS 1184221-15-5)
- 2-((Phenylamino)methyl)phenol (CAS 3526-45-2)
- (1R,2S)-Ethyl 2-hydroxycyclobutanecarboxylate (CAS 251569-86-5)
- (R)-Benzyl 3-((S)-2-aminopropanamido)pyrrolidine-1-carboxylate (CAS 1401665-96-0)
- tert-Butyl 7-amino-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 2089334-28-9)
- N-cyclopropyl-3-iodo-N-methylbenzamide (CAS 1247720-63-3)
- 2-((4-(Isopropyl(methyl)amino)cyclohexyl)amino)acetic acid (CAS 1353973-45-1)
- 5-Bromo-2,3-dimethylaniline (CAS 194805-15-7)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
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