2-(Difluoromethoxy)phenylacetic acid CAS 86867-68-7
| CAS No. | 86867-68-7 |
| Molecular Formula | C9H8F2O3 |
| Molecular Weight | 202.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 202.15 g/mol gives 2-(Difluoromethoxy)phenylacetic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(Difluoromethoxy)phenylacetic acid (CAS 86867-68-7), molecular formula C9H8F2O3 and molecular weight 202.15 g/mol, is a CATO reference standard with documented purity and traceability.
2-(Difluoromethoxy)phenylacetic acid (C9H8F2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(Difluoromethoxy)phenylacetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8F2O3 |
| Molecular Weight | 202.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 2-(Difluoromethoxy)-4-methoxybenzaldehyde (CAS 1247613-99-5)
- 3-(difluoromethoxy)-4-methylbenZoic acid (CAS 1249751-97-0)
- 4-(Difluoromethoxy)-3-methylbenzoic acid (CAS 1427373-23-6)
- 3-(Difluoromethoxy)-5-methylbenzoic acid (CAS 1427403-26-6)
- 3-Difluoromethoxy-4-methoxybenzaldehyde (CAS 153587-11-2)
- 2-Difluoromethoxy-6-methoxybenzaldehyde (CAS 1803811-37-1)
- 3-Difluoromethoxy-5-methoxybenzaldehyde (CAS 1804886-83-6)
- 4-Difluoromethoxy-2-methoxybenzaldehyde (CAS 1806276-62-9)
Recommended Standards
- 2-(difluoromethoxy)-5-methoxybenzaldehyde (CAS 294860-70-1)
- 2,2-difluoro-3-hydroxy-3-phenylpropanoic acid (CAS 681240-18-6)
- 2-(Difluoromethoxy)-3-methoxybenzaldehyde (CAS 730949-79-8)
- 2,3-Difluoro-4-(methoxymethoxy)benzaldehyde (CAS 2586126-70-5)
- Ethyl 6-bromoimidazo[1,2-a]pyridine-8-carboxylate (CAS 1799498-04-6)
- 5-(4-Ethoxyphenyl)-1H-pyrazol-3-amine (CAS 129117-13-1)
- 4,4'-(Thiazolo[5,4-d]thiazole-2,5-diyl)dianiline (CAS 4416-79-9)
- 4-Chloro-2-(tributylstannyl)pyrimidine (CAS 155191-66-5)
- (2,4-Difluoro-phenyl)-prop-2-ynyl-amine (CAS 1048922-02-6)
- Ethyl 2-((2-(2,3-dimethoxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)acetate (CAS 331459-67-7)
- Carfilzomib Impurity D4 (CAS CATO-C4X-102259)
- 3-(isocyanatomethyl)-1-methyl-1,2,4-triazole (CAS 2795115-66-9)
- 6-(propan-2-yl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS 935542-80-6)
- Tau Peptide (294-305) (human) trifluoroacetate salt (CAS 1428135-29-8)
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