4-(4-Amino-2-fluorophenoxy)picolinamide CAS 868733-71-5
| CAS No. | 868733-71-5 |
| Molecular Formula | C12H10FN3O2 |
| Molecular Weight | 247.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(4-Amino-2-fluorophenoxy)picolinamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(4-Amino-2-fluorophenoxy)picolinamide (CAS 868733-71-5) is a high-purity analytical reference standard with the molecular formula C12H10FN3O2 and a molecular weight of 247.23 g/mol.
Structurally, 4-(4-Amino-2-fluorophenoxy)picolinamide (C12H10FN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 247.23 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(4-Amino-2-fluorophenoxy)picolinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10FN3O2 |
| Molecular Weight | 247.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- Methyl-2-amino-4-(4-fluorophenyl)pyrimidine-5-carboxylate (CAS 1133115-54-4)
- 4-(4-Amino-3-fluorophenoxy)picolinamide (CAS 757251-54-0)
- 2-Amino-1-(2,5-difluorophenyl)-4,5-dimethyl-1H-pyrrole-3-carbonitrile (CAS 1094274-70-0)
- 2-Amino-1-(2,6-difluorophenyl)-4,5-dimethyl-1H-pyrrole-3-carbonitrile (CAS 1094274-74-4)
- 2-Amino-1-(2,4-difluorophenyl)-4,5-dimethyl-1H-pyrrole-3-carbonitrile (CAS 1094279-38-5)
- 2-Amino-1-(3,5-difluorophenyl)-4,5-dimethyl-1H-pyrrole-3-carbonitrile (CAS 1094279-43-2)
- 2-Amino-1-(3,4-difluorophenyl)-4,5-dimethyl-1H-pyrrole-3-carbonitrile (CAS 1152665-23-0)
- 2-Amino-1-(2,3-difluorophenyl)-4,5-dimethyl-1H-pyrrole-3-carbonitrile (CAS 1285470-72-5)
Recommended Standards
- 3,3',3''-Phosphinetriyltripropanamide (CAS 4343-60-6)
- 1-n-(4-Fluorophenyl)-4-nitrobenzene-1,2-diamine (CAS 730951-10-7)
- 5-(Ethoxycarbonyl)-6-hydroxypyridine-3-sulfonic acid (CAS 334708-06-4)
- (S)-1-(3-(Pentafluoro-l6-sulfaneyl)phenyl)ethan-1-amine (CAS 2517734-25-5)
- 7-(3,5-Dibromophenoxy)heptanoic acid (CAS 1820683-85-9)
- 2-(Ethylamino)-3-(4-iodo-1h-pyrazol-1-yl)-2-methylpropanamide (CAS 1343167-63-4)
- 3-(4-(tert-Butyl)benzyl)-6,8-dichloroquinazolin-4(3H)-one (CAS 853318-65-7)
- 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-N-methylethan-1-amine (CAS 880361-81-9)
- 1-(Tetrahydrofuran-2-carbonyl)piperidine-4-carboxylic acid (CAS 926214-32-6)
- 3-(6-Aminopyridin-2-yl)propanoic acid (CAS 153140-16-0)
- Flibanserin Impurity 14 (CAS 191977-79-4)
- Ethyl 4-amino-3-phenylbutanoate (CAS 79133-14-5)
- 2-Fluoro-6-trifluoromethylaniline (CAS 144851-61-6)
- Liraglutide Impurity 25 (CAS CATO-C4X-199225)
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